Developmentally programmed germ cell remodelling by endodermal cell cannibalism

Yusuff Abdu

doi:10.1038/ncb3439

2016-11-14

DOI：10.1038/ncb3439

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摘要

En 中文

Primordial germ cells (PGCs) in many species associate intimately with endodermal cells, but the significance of such interactions is largely unexplored. Here, we show that Caenorhabditis elegans PGCs form lobes that are removed and digested by endodermal cells, dramatically altering PGC size and mitochondrial content. We demonstrate that endodermal cells do not scavenge lobes PGCs shed, but rather, actively remove lobes from the cell body. CED-10 (Rac)-induced actin, DYN-1 (dynamin) and LST-4 (SNX9) transiently surround lobe necks and are required within endodermal cells for lobe scission, suggesting that scission occurs through a mechanism resembling vesicle endocytosis. These findings reveal an unexpected role for endoderm in altering the contents of embryonic PGCs, and define a form of developmentally programmed cell remodelling involving intercellular cannibalism. Active roles for engulfing cells have been proposed in several neuronal remodelling events, suggesting that intercellular cannibalism may be a more widespread method used to shape cells than previously thought.

Keyword:

CLATHRIN-MEDIATED ENDOCYTOSIS

INTEGRATIVE GENOMICS VIEWER

CAENORHABDITIS-ELEGANS

C.-ELEGANS

APOPTOTIC CELLS

SORTING NEXIN-9

PHAGOCYTOSIS

CLEARANCE

MIGRATION

MEMBRANE

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期刊

Nature Cell Biology

IF:

19.1

论文数:

6.2K

被引数:

4.8W

机构

Howard Hughes Medical Institute

学者数:

1.2W

论文数: 7.8K

被引数: 6.0W

New York University

学者数:

4.4W

论文数: 3.9W

被引数: 5.8W

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