.png){kind=icon}
返回
Dietary Conjugated Linoleic Acids Decrease Leptin in Porcine Adipose Tissue
.png){kind=icon}
OA
AI
DOI：10.3945/jn.109.110627.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
We investigated the effects of dietary conjugated linoleic acids (CLA) on white adipose tissue (WAT) in heavy pigs. Twelve pigs were assigned to 1 of 2 groups supplemented with either 0 or 0.75% of a CLA preparation (isomeric mixture) and were slaughtered at 159 +/- 2.3 kg live weight. Their subcutaneous WAT was analyzed by both chemical and microanatomical methods. The WAT of CLA-fed pigs tended to have a higher protein content (P = 0.064) and smaller adipocytes (P = 0.053) than that of control (CTR) pigs. The number of proliferating preadipocytes tended to be greater (P = 0.076) in pigs fed CLA, whereas the number of apoptotic adipocytes was greater (P < 0.01) than in CTR pig. Immunohistochemistry revealed that leptin (Ob) expression was lower (P = 0.048) in adipocytes from treated pigs and Western blot quantification of Ob revealed lower levels (P < 0.05) in CLA-fed pigs. The Ob receptor was not affected by dietary CLA supplementation. Tyrosine hydroxylase activity was higher (P < 0.001) in WAT of CLA fed-pigs than in CTR. It is conceivable that the increased noradrenergic activity due to dietary CLA decreases the Ob expression, although it does not diminish the lipid content of WAT, at least in heavy pigs. This article describes the interaction between CLA and Ob in the WAT of heavy pigs and we hypothesize that there is an increased noradrenergic stimulation of lipolysis directly in the target tissue. J. Nutr. 139: 1867-1872, 2009.
Keyword:
MEAT QUALITY
SUBCUTANEOUS ADIPOSE
LIPID-METABOLISM
BODY-COMPOSITION
ADIPOCYTE SIZE
SECRETION
VARIABLES
CLA
EXPRESSION
ISOMERS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.8
论文数:
1.2W
被引数:
3.7W
机构
引用论文
Influence of dietary conjugated linoleic acids and vitamin E on meat quality, and adipose tissue in rabbits日粮共轭亚油酸和维生素e对肉质和兔脂肪组织的影响.png)
MEAT SCIENCE
MEAT SCIENCEIF6.1
PREAI
分享收藏Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in miceDIABETESOAAI
DIABETESIF7.5
OAAI分享收藏
查看更多内容