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Diffusion pseudotime robustly reconstructs lineage branching
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DOI：10.1038/nmeth.3971.png)
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The temporal order of differentiating cells is intrinsically encoded in their single-cell expression profiles. We describe an efficient way to robustly estimate this order according to diffusion pseudotime (DPT), which measures transitions between cells using diffusion-like random walks. Our DPT software implementations make it possible to reconstruct the developmental progression of cells and identify transient or metastable states, branching decisions and differentiation endpoints.
Keyword:
RNA-SEQUENCING DATA
SINGLE-CELL DATA
EXPRESSION
HETEROGENEITY
TRAJECTORIES
PROGRESSION
COMMITMENT
EMBRYO
MAPS
STEM
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32.1
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