Efficient stem cell-derived mouse embryo models for environmental studies

doi:10.1016/j.devcel.2025.08.004

2025-08-28

Christoph M Häfelfinger

Magdalena Zernicka-Goetz *

DOI：10.1016/j.devcel.2025.08.004

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摘要

En 中文

• ESCs、TSCs和可诱导GATA4-ESCs的聚集构建了小鼠iGATA4-胚状体 • iGATA4-胚状体的形成效率为80%，并且与E4.5囊胚高度相似 • 其模块化设计忠实地捕获了天然胚胎的细胞比例 • iGATA4-胚状体可用于具有胚胎样表型的多参数筛选

Keyword:

blastoid

blastocyst

screening

xenobiotics

trophectoderm

epiblast

primitive endoderm

GATA4

embryo models

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期刊

Developmental Cell

IF:

8.7

论文数:

6.3K

被引数:

3.4W

机构

California Institute of Technology

学者数:

2.9W

论文数: 2.5W

被引数: 4.9W

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