.png){kind=icon}
返回
ERK5: Structure, regulation and function
.png){kind=icon}
PRE
AI
DOI：10.1016/j.cellsig.2012.07.007.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein kinase (MAPK) family and consists of an amino-terminal kinase domain, with a relatively large carboxy-terminal of unique structure and function that makes it distinct from other MAPK members. It is ubiquitously expressed in numerous tissues and is activated by a variety of extracellular stimuli, such as cellular stresses and growth factors, to regulate processes such as cell proliferation and differentiation. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade plays a critical role in cardiovascular development and vascular integrity. Recent data points to a potential role in pathological conditions such as cancer and tumour angiogenesis. This review focuses on the physiological and pathological role of ERK5, the regulation of this kinase and the recent development of small molecule inhibitors of the ERK5 signalling cascade. (C) 2012 Elsevier Inc. All rights reserved.
Keyword:
Extracellular-signal-regulated kinase 5 (ERK5)
Big mitogen-activated protein kinase-1 (BMK1)
Mitogen-activated protein kinase (MAPK)
Angiogenesis
期刊
IF:
3.7
论文数:
7.2K
被引数:
1.5W
机构
引用论文
Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.png)
EMBO JOURNAL
OAAI
EMBO JOURNALIF8.3
OAAI分享收藏Comprehensive Gene Expression Analysis of Human Embryonic Stem Cells during Differentiation into Neural CellsPLoS ONE
OAAI
PLoS ONEIF0
OAAI分享收藏Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to humanPHYSIOLOGICAL REVIEWS
PHYSIOLOGICAL REVIEWSIF28.7
PREAI
分享收藏Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload-Induced Apoptosis in the HeartCIRCULATION RESEARCHOAAI
CIRCULATION RESEARCHIF16.2
OAAI分享收藏分享收藏
查看更多内容