Germ cell chromatin†

doi:10.1093/biolre/ioaf165

2025-08-01

Stylianos Bakoulis

Kathleen R. Stewart-Morgan *

DOI：10.1093/biolre/ioaf165

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摘要

En 中文

在哺乳动物配子发生过程中，染色质景观尤为动态。原始生殖细胞（PGCs）是成熟雄性和雌性配子的前体，是一种短暂且数量稀少的细胞群体，经历深刻的表观遗传重编程。我们对这一过程的了解主要来自对小鼠和人PGCs的描述性研究，以及小鼠的功能性研究。如今，表观遗传图谱和体外配子发生技术的进步正在促进对生殖细胞染色质的更深入研究。在此，我们结合小鼠和人PGCs的染色质动力学背景，回顾了这些发现。

Keyword:

primordial germ cells

reprogramming

chromatin

epigenetics

DNA methylation

histone modifications

in vitro gametogenesis

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Biology of Reproduction

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University of Copenhagen

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