How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex

doi:10.1016/j.celrep.2024.114011

2024-04-01

Alexander C. Jones

Jian Wu

Susan S. Taylor *

DOI：10.1016/j.celrep.2024.114011

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Fatalska et al.(1) use an interdisciplinary strategy to elucidate how an intrinsically disordered regulatory subunit of protein phosphatase 1 binds trimeric eIF2 and positions the phosphatase-substrate complex for dephosphorylation. As validation, they show that a disease mutation abolishes the interaction.

期刊

Cell Reports

IF:

6.9

论文数:

1.7W

被引数:

10.2W

机构

salk institute

学者数:

3.1K

论文数: 2.2K

被引数: 8

University of California System

学者数:

37.7W

论文数: 33.8W

被引数: 6.6K

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