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J

Jian Wu

University of California

31H指数
99论文数
4.9K被引数
收录论文 30
发表时间
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A small molecule reduces both parkinsonism and l-dopa–induced dyskinesia in animal models of Parkinson’s disease一种小分子在帕金森病动物模型中同时降低帕金森症状和左旋多巴诱导的运动障碍
errScience Translational Medicine
IF14.6
err2026-07-15
err0
PREAI
errAarash Bordbar; Bernard Bloem; Colton Lloyd; Tom H. Johnston; Jay S. Schneider; Erwan Bezard; Elsa Pioli; Qin Li; Caesar Tawfeeq; Nathan Vu Pham; Gary Huber; Jian Wu; Michael P. Hill; Jonathan M. Brotchie; J. Andrew McCammon; Friedrich W. Herberg; Susan Taylor; David M. Weiner; Kalpana Merchant; Iman Famili
err分享
err收藏
Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation蛋白激酶A调节亚基Iβ变体的功能分化：N3A基序在PKA调控中的重要性
errFEBS JOURNAL
IF4.2
err2025-12-01
err0
errOAAI
errWallbott, Maximilian; Weng, Jui-Hung; Pane, Valeria; Ma, Yuliang; Wu, Jian; Taylor, Susan S.; Herberg, Friedrich W.
err分享
err收藏
Structural insights and biophysical characterization of p90RSK2:ERK2 complexp90RSK2:ERK2复合物的结构解析与生物物理表征
errBIOCHEMICAL JOURNAL
IF4.3
err2025-12-01
err0
PREAI
errKobori, Evan Kazuo; Nguyen, Hoang Phuong My; Wu, Jian; Chen, Katherine; Malinovski, Rodeon; Taylor, Susan
err分享
err收藏
C-spine mutations of protein kinase C and Akt as a novel generalizable approach to create stable pseudokinases蛋白激酶C和Akt的C-spine突变作为一种创建稳定假激酶的新型可推广方法
errJournal of Biological Chemistry
IF3.9
err2025-11-07
err0
errOAAI
errStefanie J. Hodapp; Tiffany H. Kao; Jian Wu; Nileeka Balasuriya; Corina E. Antal; Susan S. Taylor; Alexandra C. Newton
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N3A motifs in RIβ mediate allosteric crosstalk between cAMP and ATP in PKA activationN3A基序在RIβ中调节cAMP与ATP在PKA激活中的别构交叉 talk
errProtein Science
IF5.2
err2025-10-18
err0
errOAAI
errJian Wu; Jessica G. H. Bruystens; Puspashree Sahoo; José Bubis; Rodrigo A. Maillard; Susan S. Taylor; Ronit Ilouz
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Allosteric binding cooperativity in kinases signaling, signalopathies, and drug development别构结合协同性在激酶信号传导、信号通路疾病及药物开发中的作用
errCurrent Opinion in Structural Biology
IF7
err2025-10-16
err0
PREAI
errCristina Olivieri; Jian Wu; Susan S. Taylor; Gianluigi Veglia
err分享
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An alternative pocket for binding the N-degrons by the UBR1 and UBR2 ubiquitin E3 ligasesUBR1和UBR2泛素E3连接酶结合N-降解子的替代口袋
errProtein Science
IF5.2
err2025-07-28
err0
errOAAI
errShih-Ting Huang; Dai-Hua Chen; Tianchen Ren; Nicole Thomas; Jian Wu; Banumathi Sankaran; Renee Jones; Susan Taylor; Yuan Chen
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err收藏
RedOx regulation of LRRK2 kinase activity by active site cysteines
errNPJ PARKINSONS DISEASE
IF8.2
err2024-04-03
err1
errOAAI
errTrilling, Chiara R.; Weng, Jui-Hung; Sharma, Pallavi Kaila; Nolte, Viktoria; Wu, Jian; Ma, Wen; Boassa, Daniela; Taylor, Susan S.; Herberg, Friedrich W.
err分享
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How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex
errCELL REPORTS
IF6.9
err2024-04-01
err0
errOAAI
errJones, Alexander C.; Wu, Jian; Taylor, Susan S.
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Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk
errBIOCHEMICAL JOURNAL
IF4.3
err2024-02-19
err1
errOAAI
errSharma, Pallavi Kaila; Weng, Jui-Hung; Manschwetus, Jascha T.; Wu, Jian; Ma, Wen; Herberg, Friedrich W.; Taylor, Susan S.
err分享
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Capturing the domain crosstalk in full length LRRK2 and LRRK2RCKW
errBIOCHEMICAL JOURNAL
IF4.3
err2023-06-12
err3
errOAAI
errStoermer, Eliza; Weng, Jui-Hung; Wu, Jian; Bertinetti, Daniela; Sharma, Pallavi Kaila; Ma, Wen; Herberg, Friedrich W.; Taylor, Susan S.
err分享
err收藏
Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors
errACS CHEMICAL BIOLOGY
IF3.8
err2023-04-12
err11
errOAAI
errWeng, Jui-Hung; Ma, Wen; Wu, Jian; Sharma, Pallavi Kaila; Silletti, Steve; McCammon, J. Andrew; Taylor, Susan
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Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase AEdmond Fischer的激酶遗产: 蛋白激酶抑制剂和蛋白激酶A的历史
errIUBMB LIFE
IF3.2
err2023-02-28
err6
errOAAI
errTaylor, Susan S.; Herberg, Friedrich W.; Veglia, Gianluigi; Wu, Jian
err分享
err收藏
The Forgotten PKAs: New Insights Revealed by the First Crystal Structure of a PKA C Beta Splice Variant, Cβ4ab
errFASEB JOURNAL
IF4.2
err2022-05-13
err0
PREAI
errBruystens, Jessica H.; Wu, Jian; Wallbott, Maximilian; Bertinetti, Daniela; Herberg, Friedrich W.; Taylor, Susan S.
err分享
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The Tails of Protein Kinase A
errMOLECULAR PHARMACOLOGY
IF3
err2022-04-01
err15
errOAAI
errTaylor, Susan S.; Soberg, Kristoffer; Kobori, Evan; Wu, Jian; Pautz, Sabine; Herberg, Friedrich W.; Skalhegg, Bjorn Steen
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PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies
errBIOCHEMICAL JOURNAL
IF4.3
err2021-06-11
err22
PREAI
errTaylor, Susan S.; Wallbott, Maximilian; Machal, Erik M. F.; Soberg, Kristoffer; Ahmed, Faihaa; Bruystens, Jessica; Vu, Lily; Baker, Blaine; Wu, Jian; Raimondi, Francesco; Ongeri, Elimelda M.; Herberg, Friedrich W.; Skalhegg, Bjorn S.
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Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-05-18
err13
errOAAI
errJafari, Naeimeh; Del Rio, Jason; Akimoto, Madoka; Byun, Jung Ah; Boulton, Stephen; Moleschi, Kody; Alsayyed, Yousif; Swanson, Pascale; Huang, Jinfeng; Pomier, Karla Martinez; Lee, Chi; Wu, Jian; Taylor, Susan S.; Melacini, Giuseppe
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From structure to the dynamic regulation of a molecular switch: A journey over 3 decades
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2021-01-01
err62
errOAAI
errTaylor, Susan S.; Wu, Jian; Bruystens, Jessica G. H.; Del Rio, Jason C.; Lu, Tsan-Wen; Kornev, Alexandr P.; Ten Eyck, Lynn F.
err分享
err收藏
PKA RIα Holoenzyme Structure Reveals ATP-Dependent Dynamics and Allosteric Regulation in Isoform-Specific Manner
errFASEB JOURNAL
IF4.2
err2020-04-18
err0
errOAAI
errLu, Tsan-Wen; Wu, Jian; Aoto, Phillip; Weng, Jui-Hung; Ahuja, Lalima; Sun, Nicholas; Taylor, Susan
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Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2019-07-30
err30
errOAAI
errLu, Tsan-Wen; Wu, Jian; Aoto, Phillip C.; Weng, Jui-Hung; Ahuja, Lalima G.; Sun, Nicholas; Cheng, Cecilia Y.; Zhang, Ping; Taylor, Susan S.
err分享
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研究方向

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合作学者
合作期刊
J
J. Andrew McCammon
H 指数: 134 · 论文数: 1.1K
G
Günter Blobel
H 指数: 128 · 论文数: 329
J
J. Craig Venter
H 指数: 120 · 论文数: 277
S
Susan S. Taylor
H 指数: 110 · 论文数: 716
A
Alexandra C. Newton
H 指数: 77 · 论文数: 337
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