.png){kind=icon}
返回
Identification of dynamic protein complexes based on fruit fly optimization algorithm
.png){kind=icon}
PRE
AI
DOI：10.1016/j.knosys.2016.05.019.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Protein complexes play a significant role in understanding cellular life in postgenomic era. Yet up to now, the existing protein complex detection algorithms are mostly applied to static PPI networks and their performance is not very ideal for the deficiency of low efficiency and sensitive to noisy data. In this paper, a novel algorithm named Fruit fly Optimization Clustering Algorithm (FOCA), is proposed to identify dynamic protein complexes by combining Fruit fly Optimization Algorithm (FOA) and gene expression profiles. Particularly, we first find the always active proteins by the stable interactions of the dynamic PPI network and detect protein complex cores from those always active proteins. Then, FOA is used to merge of the rest proteins in every dynamic sub-network to their corresponding protein complex cores. The experimental results on DIP dataset demonstrate that FOCA is very effective in detecting protein complexes than the state-of-the-art complex detection techniques. (C) 2016 Elsevier B.V. All rights reserved.
Keyword:
Dynamic protein-protein interaction network (DPIN)
Fruit fly optimization algorithm
Gene expression
Protein complex
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
K
IF:
7.6
论文数:
1.3W
被引数:
4.5W
机构
引用论文
Construction and application of dynamic protein interaction network based on time course gene expression data基于时程基因表达数据的动态蛋白质相互作用网络构建及应用.png)
PROTEOMICS
PROTEOMICSIF3.9
PREAI
分享收藏Detecting overlapping protein complexes in protein-protein interaction networksNATURE METHODS
OAAI
NATURE METHODSIF32.1
OAAI分享收藏In vitro reconstruction of a tissue-engineered endothelialized bladder from a single porcine biopsy从单个猪活检中体外重建组织工程化的内皮化膀胱
PREAI
分享收藏
Dynamic protein interaction network construction and applications蛋白质动态相互作用网络的构建及应用PROTEOMICS
PROTEOMICSIF3.9
PREAI
分享收藏A human phenome-interactome network of protein complexes implicated in genetic disordersNATURE BIOTECHNOLOGYOAAI
NATURE BIOTECHNOLOGYIF41.7
OAAI分享收藏分享收藏
查看更多内容