Linaclotide First Global Approval

McWilliams, Vanessa

doi:10.2165/11470590-000000000-00000

2012-11-01

PRE

McWilliams, Vanessa

Whiteside, Glenn *

McKeage, Kate

DOI：10.2165/11470590-000000000-00000

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Linaclotide is a once-daily, orally administered, first-in-class agonist of guanylate cyclase-C that is minimally absorbed. It is being developed to treat gastrointestinal disorders by Ironwood Pharmaceuticals and its partners, Forest Laboratories (North America), Almirall (Europe) and Astellas Pharma (Asia-Pacific). Linaclotide has received its first global approval in the US for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CC), and a marketing submission has been filed in the EU for IBS-C. This article summarizes the milestones in the development of linaclotide leading to this first approval for IBS-C and CIC.

Keyword:

GUANYLATE-CYCLASE C

EFFICACY

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