.png){kind=icon}
返回
Microfluidic organs-on-chips
.png){kind=icon}
PRE
AI
DOI：10.1038/nbt.2989.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing methods that contains continuously perfused chambers inhabited by living cells arranged to simulate tissue-and organ-level physiology. By recapitulating the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments and vascular perfusion of the body, these devices produce levels of tissue and organ functionality not possible with conventional 2D or 3D culture systems. They also enable high-resolution, real-time imaging and in vitro analysis of biochemical, genetic and metabolic activities of living cells in a functional tissue and organ context. This technology has great potential to advance the study of tissue development, organ physiology and disease etiology. In the context of drug discovery and development, it should be especially valuable for the study of molecular mechanisms of action, prioritization of lead candidates, toxicity testing and biomarker identification.
Keyword:
PRIMARY HUMAN HEPATOCYTES
PLURIPOTENT STEM-CELL
IN-VITRO MODEL
A-CHIP
BREAST-CANCER
HUMAN LIVER
EXTRACELLULAR-MATRIX
HEPATIC-CLEARANCE
ENDOTHELIAL-CELLS
GENE-EXPRESSION
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
41.7
论文数:
1.2W
被引数:
10.1W
机构
引用论文
Noninvasive detection of skeletal muscle underperfusion with near-infrared spectroscopy in patients with heart failure.心力衰竭患者骨骼肌灌注不足的近红外光谱无创检测。.png)
Circulation
CirculationIF0
PREAI
分享收藏分享收藏
Fabrication of superhydrophobic, self-cleaning and anti-icing ZnO/PTFE-SiO2 nano-composite thin film
PREAI
分享收藏A HCN4+cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cellsNATURE CELL BIOLOGY
NATURE CELL BIOLOGYIF19.1
PREAI
分享收藏
查看更多内容