Mo' m1A, mo' problems

Linamarie Miller

doi:10.1016/j.chembiol.2023.12.013

2024-01-01

Linamarie Miller

James Shorter *

DOI：10.1016/j.chembiol.2023.12.013

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摘要

En 中文

CAG-repeat expansions underlie fatal neurodegenerative disorders. In a lodestar study published in a recent issue of Nature, Sun et al.1 identify a writer and eraser of N1-methyladenosine (m1A) modifications of CAGrepeat RNA. They establish that m1A modifications in CAG-repeat expanded RNA promote neurodegeneration and aberrant phase transitions of TDP-43. These findings suggest therapeutic strategies for CAG-repeat expansion disorders.

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期刊

Cell Chemical Biology

IF:

7.2

论文数:

1.8K

被引数:

1.1W

机构

University of Pennsylvania

学者数:

4.3K

论文数: 1.3K

被引数: 539

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