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Mouse phenotyping
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DOI：10.1016/j.ymeth.2010.08.006.png)
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摘要
En 中文
Model organisms like the mouse are important tools to learn more about gene function in man. Within the last 20 years many mutant mouse lines have been generated by different methods such as ENU mutagenesis, constitutive and conditional knock-out approaches, knock-down, introduction of human genes, and knock-in techniques, thus creating models which mimic human conditions. Due to pleiotropic effects, one gene may have different functions in different organ systems or time points during development. Therefore mutant mouse lines have to be phenotyped comprehensively in a highly standardized manner to enable the detection of phenotypes which might otherwise remain hidden. The German Mouse Clinic (GMC) has been established at the Helmholtz Zentrum Munchen as a phenotyping platform with open access to the scientific community (www.mousclinic.de; [1]). The GMC is a member of the EUMOD-IC consortium which created the European standard workflow EMPReSSslim for the systemic phenotyping of mouse models (http://www.eumodic.org/ [2]). (C) 2010 Elsevier Inc. All rights reserved.
Keyword:
TANDEM MASS-SPECTROMETRY
INSULIN-RESISTANCE
NATRIURETIC-PEPTIDE
MUTAGENESIS PROJECT
EYE-MOVEMENTS
T-CELLS
MICE
EXPRESSION
PROTEIN
MODELS
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4.3
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4.8K
被引数:
2.4W
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PANTHER: A library of protein families and subfamilies indexed by functionPANTHER: 按功能索引的蛋白质家族和亚家族文库.png)
GENOME RESEARCH
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