.png){kind=icon}
返回
PharmVar GeneFocus: SLCO1B1
.png){kind=icon}
OA
AI
DOI：10.1002/cpt.2705.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter. Genetic variation within the SLCO1B1 gene locus impacts drug transport, which can lead to altered pharmacokinetic profiles of several commonly prescribed drugs. Variable OATP1B1 function is of particular importance regarding hepatic uptake of statins and the risk of statin-associated musculoskeletal symptoms. To introduce this important drug transporter gene into the PharmVar database and serve as a unified reference of haplotype variation moving forward, an international group of gene experts has performed an extensive review of all published SLCO1B1 star alleles. Previously published star alleles were self-assigned by authors and only loosely followed the star nomenclature system that was first developed for cytochrome P450 genes. This nomenclature system has been standardized by PharmVar and is now applied to other important pharmacogenes such as SLCO1B1. In addition, data from the 1000 Genomes Project and investigator-submitted data were utilized to confirm existing haplotypes, fill knowledge gaps, and/or define novel star alleles. The PharmVar-developed SLCO1B1 nomenclature has been incorporated by the Clinical Pharmacogenetics Implementation Consortium (CPIC) 2022 guideline on statin-associated musculoskeletal symptoms.
Keyword:
ANION TRANSPORTING POLYPEPTIDE
CONSORTIUM CPIC GUIDELINE
OATP-C SLC21A6
ENCODING OATP1B1
INDUCED MYOPATHY
ROTOR SYNDROME
PHARMACOKINETICS
PRAVASTATIN
IMPACT
POLYMORPHISMS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
C
IF:
5.5
论文数:
8.6K
被引数:
1.9W
机构
引用论文
.png){kind=icon}
Ca(2+)-dependent inactivation of cardiac L-type Ca2+ channels does not affect their voltage sensor.OAAI
OAAI分享收藏
查看更多内容