Polθ helicase: drive or reverse

doi:10.1038/nsmb.3510

2017-12-01

PRE

Judith L. Campbell *

Hongzhi Li

DOI：10.1038/nsmb.3510

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摘要

En 中文

The helicase intrinsic to DNA polymerase theta (Pol theta), the versatile mediator of microhomology-based repair of DNA double-strand breaks and stalled replication forks, is now revealed to be a member of an elite group of proteins known as annealing helicases. This small family of enzymes remodels DNA intermediates in multiple repair processes that are crucial to preserving genome stability and warding off cancer and aging.

Keyword:

DNA-POLYMERASE THETA

STRAND BREAK REPAIR

RECOMBINATION

MECHANISM

PATHWAY

TUMORS

CELLS

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期刊

Nature Structural and Molecular Biology

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10.1

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4.8K

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2.8W

机构

California Institute of Technology

学者数:

2.9W

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被引数: 4.9W

City of Hope

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9.2K

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