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Probiotic and microbiota engineering for practical applications
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DOI：10.1016/j.cofs.2024.101130.png)
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摘要
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The last decades have witnessed amazing advances in engineering individual microbes for practical applications. However, engineering microbial consortia is a recent development, opening a new path for diverse applications, including curing gut diseases, solving food shortages, enabling sustainable bioproduction, mitigating pollution, and potentially addressing the climate crisis. In this perspective article, I will summarize recent technological innovations in synthetic biology that enable probiotic and microbiome engineering. Additionally, I will cover associated issues such as biosafety and biocontainment when the probiotics and microbiota are engineered. Given the complexity of global problems that are difficult to solve using a single microbe, this perspective will guide the research community to a better future with exciting potential applications.
Keyword:
GUT MICROBIOTA
KILL SWITCHES
BACTERIA
DIAGNOSTICS
SYSTEM
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9.1
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