.png){kind=icon}
返回
Protein Complex-Based Analysis Framework for High-Throughput Data Sets
.png){kind=icon}
OA
AI
DOI：10.1126/scisignal.2003629.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Analysis of high-throughput data increasingly relies on pathway annotation and functional information derived from Gene Ontology. This approach has limitations, in particular for the analysis of network dynamics over time or under different experimental conditions, in which modules within a network rather than complete pathways might respond and change. We report an analysis framework based on protein complexes, which are at the core of network reorganization. We generated a protein complex resource for human, Drosophila, and yeast from the literature and databases of protein-protein interaction networks, with each species having thousands of complexes. We developed COMPLEAT (http://www.flyrnai.org/compleat), a tool for data mining and visualization for complex-based analysis of high-throughput data sets, as well as analysis and integration of heterogeneous proteomics and gene expression data sets. With COMPLEAT, we identified dynamically regulated protein complexes among genome-wide RNA interference data sets that used the abundance of phosphorylated extracellular signal-regulated kinase in cells stimulated with either insulin or epidermal growth factor as the output. The analysis predicted that the Brahma complex participated in the insulin response.
Keyword:
MOLECULAR INTERACTION DATABASE
RECEPTOR TYROSINE KINASE
INTERACTION NETWORK
INSULIN-RECEPTOR
CELL-SIZE
PHOSPHORYLATION
GROWTH
INTEGRATION
EXPRESSION
LANDSCAPE
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
6.6
论文数:
3.0K
被引数:
1.4W
机构
引用论文
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists生物信息学富集工具: 通往大型基因列表综合功能分析的路径.png)
NUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏A human phenome-interactome network of protein complexes implicated in genetic disordersNATURE BIOTECHNOLOGYOAAI
NATURE BIOTECHNOLOGYIF41.7
OAAI分享收藏
查看更多内容