Meghana Kulkarni - Publications, H-index & Citations

Meghana Kulkarni

silicon therapeutics, boston, ma, usa

17H指数

57论文数

3.5K被引数

收录论文 14

发表时间

A novel approach for first-in-human dose selection using population dose-response modelling to find a minimum anticipated biological effect level 一种利用群体剂量-反应模型确定最小预期生物效应水平，以进行首次人体试验剂量选择的新方法

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2025-04-27

PREAI

Lin Yuan; Meghana Kulkarni; Evan Chiswick; Cheryl Koh; Peter Sandy; Salah Nabhan; Woody Sherman; Melissa Johnson; Judy Wang; Gerald Falchook; Jennifer Johnson; Christopher Winter; Humphrey Gardner; Arijit Chakravarty; Madison Stoddard

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-02-08

PREAI

Winter-Holt, Jon J.; Bardelle, Catherine; Chiarparin, Elisabetta; Dale, Ian L.; Davey, Paul R. J.; Davies, Nichola L.; Denz, Christopher; Fillery, Shaun M.; Guerot, Carine M.; Han, Fujin; Hughes, Samantha J.; Kulkarni, Meghana; Liu, Zhaoqun; Milbradt, Alexander; Moss, Thomas A.; Niu, Huijun; Patel, Joe; Rabow, Alfred A.; Schimpl, Marianne; Shi, Junjie; Sun, Dongqing; Yang, Dejian; Guichard, Sylvie

TRIAL OF SNX281, A SYSTEMICALLY DELIVERED SMALL MOLECULE STING AGONIST, IN SOLID TUMORS AND LYMPHOMAS 全身递送的小分子STING激动剂SNX281在实体瘤和淋巴瘤中的试验

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2021-11-10

OAAI

Wang, Judy; Falchook, Gerald; Nabhan, Salah; Kulkarni, Meghana; Sandy, Peter; Dosunmu, Ololade; Gardner, Humphrey; Bendell, Johanna; Johnson, Melissa

True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy

MOLECULAR CANCER THERAPEUTICS

IF5.5

2019-12-01

PREAI

Kulkarni, Meghana M.; Dwight, Timothy; Marino, Kristen; Allen, Bryce K.; Taimi, Mohammed; Bastos, Cecilia; Lai, Sujen; Koh, Cheryl; Samant, Ramya; Tesar, Bethany; Huang, Huang; Chamberlain, Brian; Rice, James M.; Tan, Dazhi; Lin, Zhixiong; Shechter, Sharon; Li, Stella; Sparks, Sam; Soutter, Holly; Swann, Steven; Sherman, Woody; Winter, Christopher

Identification of a novel RNA processing mechanism of intronic readthrough to a transcriptional stop leading to truncated transcript expression, including FANCI and ATM, upon CDK12 inhibition

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-01-01

PREAI

Denz, Christopher; Johannes, Jeffrey; Yao, Yi; Kulkarni, Meghana; Dulak, Austin; Guan, Nin; Su, Nancy; Lamb, Michelle; Fawell, Stephen; Guichard, Sylvie

Discovery of a potent and selective ATAD2 inhibitor with antiproliferative activity in breast cancer models

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-01-01

PREAI

Kulkarni, Meghana M.; Winter, Jon; Whalley, David; Dale, Ian; Denz, Christopher; Guan, Nin; Bhavsar, Deepa; Zhang, Andrew; Rasmusson, Timothy; Fretland, Adrian; Guichard, Sylvie M.

Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes

JCI INSIGHT

IF6.1

2016-09-08

110

OAAI

Lizotte, Patrick H.; Ivanova, Elena V.; Awad, Mark M.; Jones, Robert E.; Keogh, Lauren; Liu, Hongye; Dries, Ruben; Almonte, Christina; Herter-Sprie, Grit S.; Santos, Abigail; Feeney, Nora B.; Paweletz, Cloud P.; Kulkarni, Meghana M.; Bass, Adam J.; Rustgi, Anil K.; Yuan, Guo-Cheng; Kufe, Donald W.; Janne, Pasi A.; Hammerman, Peter S.; Sholl, Lynette M.; Hodi, F. Stephen; Richards, William G.; Bueno, Raphael; English, Jessie M.; Bittinger, Mark A.; Wong, Kwok-Kin

An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling

CELL REPORTS

IF6.9

2016-09-01

OAAI

Vinayagam, Arunachalam; Kulkarni, Meghana M.; Sopko, Richelle; Sun, Xiaoyun; Hu, Yanhui; Nand, Ankita; Villalta, Christians; Moghimi, Ahmadali; Yang, Xuemei; Mohr, Stephanie E.; Hong, Pengyu; Asara, John M.; Perrimon, Norbert

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints 对治疗性PD-1阻断的适应性抵抗与替代免疫检查点的上调有关

NATURE COMMUNICATIONS

IF15.7

2016-02-17

1.3K

OAAI

Koyama, Shohei; Akbay, Esra A.; Li, Yvonne Y.; Herter-Sprie, Grit S.; Buczkowski, Kevin A.; Richards, William G.; Gandhi, Leena; Redig, Amanda J.; Rodig, Scott J.; Asahina, Hajime; Jones, Robert E.; Kulkarni, Meghana M.; Kuraguchi, Mari; Palakurthi, Sangeetha; Fecci, Peter E.; Johnson, Bruce E.; Janne, Pasi A.; Engelman, Jeffrey A.; Gangadharan, Sidharta P.; Costa, Daniel B.; Freeman, Gordon J.; Bueno, Raphael; Hodi, F. Stephen; Dranoff, Glenn; Wong, Kwok-Kin; Hammerman, Peter S.

A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2

SCIENTIFIC REPORTS

IF3.9

2016-02-03

OAAI

Breitkopf, Susanne B.; Yang, Xuemei; Begley, Michael J.; Kulkarni, Meghana; Chiu, Yu-Hsin; Turke, Alexa B.; Lauriol, Jessica; Yuan, Min; Qi, Jie; Engelman, Jeffrey A.; Hong, Pengyu; Kontaridis, Maria I.; Cantley, Lewis C.; Perrimon, Norbert; Asara, John M.

Functional genomics reveals genetic dependencies in gastric cancer

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Kulkarni, Meghana M.; Gurumurthy, Sushma; Schmidt-Kittler, Oleg; Berglund, Jason; Hulton, Christopher H.; Wilson, David J.; Jakubosky, David; Michaud, Daniel; Jones, Robert E.; Sjoblom, Nicole M.; McSweeney, Russell; Zhou, Hongwei; Venkatakrishnan, Annapurna; Jensen, Karin J.; Zhang, Jingxin; Mankoo, Parminder K.; Pollard, Jack; Winter, Christopher; Jaenne, Pasi A.; Wong, Kwok-Kin; Richon, Victoria M.; English, Jessie M.; Bittinger, Mark A.

Protein Complex-Based Analysis Framework for High-Throughput Data Sets

SCIENCE SIGNALING

IF6.6

2013-02-26

OAAI

Vinayagam, Arunachalam; Hu, Yanhui; Kulkarni, Meghana; Roesel, Charles; Sopko, Richelle; Mohr, Stephanie E.; Perrimon, Norbert

Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays

NATURE METHODS

IF32.1

2006-09-21

285

PREAI