Rapid and sensitive protein complex alignment with Foldseek-Multimer

doi:10.1038/s41592-025-02593-7

2025-02-05

DOI：10.1038/s41592-025-02593-7

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摘要

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计算结构预测的进展将极大扩充当前可用的数以十万计的蛋白质复合物结构。将这些结构转化为发现需要对其进行比对，而这一过程在计算上是不切实际的。Foldseek-Multimer通过高效聚类它们的叠加向量来识别兼容的链间比对，进而计算复合物比对。Foldseek-Multimer比金标准方法快3-4个数量级，同时生成可比较的比对结果；这使得它能够在11小时内比较数十亿对复合物。Foldseek-Multimer是开源软件，可通过GitHub上的https://github.com/steineggerlab/foldseek/、https://search.foldseek.com/search/以及BFMD数据库获得。

期刊

Nature Methods

IF:

32.1

论文数:

7.3K

被引数:

12.7W

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