.png){kind=icon}
返回
RNAapt3D: RNA aptamer 3D-structural modeling database
.png){kind=icon}
OA
AI
DOI：10.1016/j.bpj.2022.09.023.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
RNA aptamers are oligonucleotides with high binding affinity and specificity for target molecules and are expected to be a new generation of therapeutic molecules and targeted delivery materials. The tertiary structure of RNA molecules and RNA-protein interaction sites are increasingly important as potential targets for new drugs. The pathological mechanisms of diseases must be understood in detail to guide drug design. In developing RNA aptamers as drugs, information about the interaction mechanisms and structures of RNA aptamer-target protein complexes are useful. We constructed a database, RNA aptamer 3D-structural modeling (RNAapt3D), consisting of RNA aptamer data that are potential drug candidates. The database includes RNA sequences and computationally predicted RNA tertiary structures based on secondary structures and implements methods that can be used to predict unknown structures of RNA aptamer-target molecule complexes. RNAapt3D should enable the design of RNA aptamers for target molecules and improve the efficiency and productivity of candidate drug selection. RNAapt3D can be accessed at https://rnaapt3d.medals.jp.
Keyword:
TERTIARY STRUCTURE PREDICTION
SECONDARY STRUCTURE
MOLECULAR-DYNAMICS
RANIBIZUMAB
PEGAPTANIB
FRAGMENT
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.1
论文数:
5.0W
被引数:
4.4W
机构
引用论文
RNAcentral 2021: secondary structure integration, improved sequence search and new member databases.png)
NUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Influence of Na+ and Mg2+ ions on RNA structures studied with molecular dynamics simulationsNUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Software News and Update AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading软件新闻和更新AutoDock Vina: 通过新的评分功能，高效的优化和多线程提高对接的速度和准确性OAAI
OAAI分享收藏
查看更多内容