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doi:10.1016/j.biopha.2022.114052

2023-01-01

DOI：10.1016/j.biopha.2022.114052

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摘要

En 中文

A major challenge in the field of diabetic wound healing is to confirm the body's intrinsic mechanism that could sense the immune system damage promptly and protect the wound from non-healing. Accumulating literature indicates that macrophage, a contributor to prolonged inflammation occurring at the wound site, might play such a role in hindering wound healing. Likewise, other immune cell dysfunctions, such as persistent neutrophils and T cell infection, may also lead to persistent oxidative stress and inflammatory reaction during diabetic wound healing. In this article, we discuss recent advances in the immune cellular components in wounds under the diabetic milieu, and the role of key signaling mechanisms that compromise the function of immune cells leading to persistent wound non-healing.

Keyword:

Immune cells

Inflammation

Diabetes

Diabetic wound healing progression

Cellular components

Signaling pathways

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期刊

Biomedicine and Pharmacotherapy

IF:

7.5

论文数:

1.6W

被引数:

8.2W

机构

fudan university

学者数:

11.8W

论文数: 7.7W

被引数: 121

shanghai university of traditional chinese medicine

学者数:

1.7W

论文数: 7.9K

被引数: 15

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