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Targeted proteomics data interpretation with DeepMRM

delete2023-07-01
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OA
AI
J
Jungkap Park
C
Christopher Wilkins
D
Dmitry M. Avtonomov
J
Jiwon Hong
S
Seunghoon Back
H
Hokeun Kim
N
Nicholas Shulman
B
Brendan MacLean
S
Sang‐Won Lee
S
Sangtae Kim *
DOI:10.1016/j.crmeth.2023.100521delete
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摘要

摘要

En 中文
Targeted proteomics is widely utilized in clinical proteomics; however, researchers often devote substantial time to manual data interpretation, which hinders the transferability, reproducibility, and scalability of this approach. We introduce DeepMRM, a software package based on deep learning algorithms for object detec-tion developed to minimize manual intervention in targeted proteomics data analysis. DeepMRM was evalu-ated on internal and public datasets, demonstrating superior accuracy compared with the community stan-dard tool Skyline. To promote widespread adoption, we have incorporated a stand-alone graphical user interface for DeepMRM and integrated its algorithm into the Skyline software package as an external tool.
Keyword:
MS
QUANTIFICATION
ABSOLUTE
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Cell Reports Methods
IF:
4.5
论文数:
938
被引数:
2.0K

机构

K
Korea University
学者数:
3.6W
论文数: 3.8W
被引数: 4.4W
U
University of Washington
学者数:
8.0W
论文数: 7.0W
被引数: 12.5W
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