arrow
返回

The selfishly selfless placenta

delete2019-12-17
delete5
delete
OA
AI
N
Nermi L. Parrow
R
Robert E. Fleming *
DOI:10.1172/JCI134272delete
delete原文链接
delete原文求助
delete分享
delete收藏
摘要

摘要

En 中文
Although iron deficiency continues to pose a problem for pregnant women and fetal development, an incomplete understanding of placental adaptation to limited iron availability has hindered efforts to identify optimal supplementation strategies. In this issue of the JCI, Sangkhae et al. used mouse models and human placentas to explore maternal, placental, and fetal responses to alterations in iron status during pregnancy. The authors identified molecular mechanisms that limit placental ability to upregulate iron transport in the setting of severe iron deficiency and explored a potential marker of placental maladaptation.
Keyword:
IRON STATUS
FETAL
HEPCIDIN
HEALTH

期刊

Journal of Clinical Investigation 封面图
Journal of Clinical Investigation
IF:
13.6
论文数:
1.5W
被引数:
11.5W

机构

S
Saint Louis University
学者数:
1.1W
论文数: 8.7K
被引数: 151
引用论文

引用论文

Copper supplementation reverses dietary iron overload-induced pathologies in mice
err2018-09-01
err21
errOAAI
errWang, Tao; Xiang, Ping; Ha, Jung-Heun; Wang, Xiaoyu; Doguer, Caglar; Flores, Shireen R. L.; Kang, Yujian James; Collins, James F.
err分享
err收藏
Effects of maternal iron status on placental and fetal iron homeostasis
err2019-12-17
err126
errOAAI
errSangkhae, Veena; Fisher, Allison L.; Wong, Shirley; Koenig, Mary Dawn; Tussing-Humphreys, Lisa; Chu, Alison; Lelic, Melisa; Ganz, Tomas; Nemeth, Elizabeta
err分享
err收藏
Impact of maternal and neonatal iron status on placental transferrin receptor expression in pregnant adolescents
err2010-11-01
err51
PREAI
errYoung, M. F.; Pressman, E.; Foehr, M. L.; McNanley, T.; Cooper, E.; Guillet, R.; Orlando, M.; McIntyre, A. W.; Lafond, J.; O'Brien, K. O.
err分享
err收藏
Role of Intestinal HIF-2α in Health and Disease
err2016-02-10
err64
errOAAI
errRamakrishnan, Sadeesh K.; Shah, Yatrik M.
err分享
err收藏
err分享
err收藏
学者 查看更多内容