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TransgeneOmics - A transgenic platform for protein localization based function exploration
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DOI：10.1016/j.ymeth.2015.10.005.png)
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The localization of a protein is intrinsically linked to its role in the structural and functional organization of the cell. Advances in transgenic technology have streamlined the use of protein localization as a function discovery tool. Here we review the use of large genomic DNA constructs such as bacterial artificial chromosomes as a transgenic platform for systematic tag-based protein function exploration. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license
Keyword:
BAC transgenesis
Recombineering
Protein localization
Genome engineering
Protein tagging
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NUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏分享收藏BAC TransgeneOmics:: a high-throughput method for exploration of protein function in mammalsNATURE METHODSOAAI
NATURE METHODSIF32.1
OAAI分享收藏Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon使用修饰的Mos1转座子在秀丽隐杆线虫中随机和靶向转基因插入NATURE METHODSOAAI
NATURE METHODSIF32.1
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Recombineering: a homologous recombination-based method of genetic engineeringNATURE PROTOCOLSOAAI
NATURE PROTOCOLSIF16
OAAI分享收藏C-elegans ORFeome version 3.1:: Increasing the coverage of 2064 ORFeome resources with improved gene predictionsGENOME RESEARCHOAAI
GENOME RESEARCHIF5.5
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