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Accelerating Drug Development Using Spatial Multi-omics

delete2024-04-04
delete3
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OA
AI
R
Richard J. A. Goodwin *
S
Stefan Platz
J
Jorge S. Reis‐Filho
S
Simon T. Barry *
DOI：10.1158/2159-8290.CD-24-0101delete
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Abstract

Abstract

En 中文
Spatial biology approaches enabled by innovations in imaging biomarker platforms and artificial intelligence-enabled data integration and analysis provide an assessment of patient and disease heterogeneity at ever-increasing resolution. The utility of spatial biology data in accelerating drug programs, however, requires balancing exploratory discovery investigations against scalable and clinically applicable spatial biomarker analysis.
Keywords:
ARTIFICIAL-INTELLIGENCE

Journal

Cancer Discovery cover
Cancer Discovery
IF:
33.3
Papers:
3.9K
Citations:
3.7W

Organization

A
AstraZeneca
Scholars:
2.1W
Papers: 1.1W
Citations: 36
Cited Papers

Cited Papers

Impact of a five-dimensional framework on R&D productivity at AstraZeneca
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IF101.8
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err269
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Whole-genome and transcriptome analysis enhances precision cancer treatment options
errANNALS OF ONCOLOGY
IF65.4
err2022-09-01
err46
errOAAI
errPleasance, E.; Bohm, A.; Williamson, L. M.; Nelson, J. M. T.; Shen, Y.; Bonakdar, M.; Titmuss, E.; Csizmok, V; Wee, K.; Hosseinzadeh, S.; Grisdale, C. J.; Reisle, C.; Taylor, G. A.; Lewis, E.; Jones, M. R.; Bleile, D.; Sadeghi, S.; Zhang, W.; Davies, A.; Pellegrini, B.; Wong, T.; Bowlby, R.; Chan, S. K.; Mungall, K. L.; Chuah, E.; Mungall, A. J.; Moore, R. A.; Zhao, Y.; Deol, B.; Fisic, A.; Fok, A.; Regier, D. A.; Weymann, D.; Schaeffer, D. F.; Young, S.; Yip, S.; Schrader, K.; Levasseur, N.; Taylor, S. K.; Feng, X.; Tinker, A.; Savage, K. J.; Chia, S.; Gelmon, K.; Sun, S.; Lim, H.; Renouf, D. J.; Jones, S. J. M.; Marra, M. A.; Laskin, J.
errShare
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Adoptive T-cell immunotherapy of chronic lymphocytic leukaemia
errBest Practice & Research Clinical Haematology
IF0
err2008-09-01
err0
errOAAI
errAaron E. Foster; Malcolm K. Brenner; Gianpietro Dotti
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CD8+ T cell states in human cancer: insights from single-cell analysis
errNATURE REVIEWS CANCER
IF66.8
err2020-02-05
err879
errOAAI
errVan der Leun, Anne M.; Thommen, Daniela S.; Schumacher, Ton N.
errShare
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Tumour heterogeneity and resistance to cancer therapies
errNATURE REVIEWS CLINICAL ONCOLOGY
IF82.2
err2017-11-08
err2.4K
PREAI
errDagogo-Jack, Ibiayi; Shaw, Alice T.
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Artificial intelligence in histopathology: enhancing cancer research and clinical oncology
errNATURE CANCER
IF28.5
err2022-09-22
err173
PREAI
errShmatko, Artem; Ghaffari Laleh, Narmin; Gerstung, Moritz; Kather, Jakob Nikolas
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Activation of Human Osteoblasts via Different Bovine Bone Substitute Materials With and Without Injectable Platelet Rich Fibrin in vitro
errFrontiers in Bioengineering and Biotechnology
IF0
err2021-02-17
err0
errOAAI
errSolomiya Kyyak; Sebastian Blatt; Eik Schiegnitz; Diana Heimes; Henning Staedt; Daniel G. E. Thiem; Keyvan Sagheb; Bilal Al-Nawas; Peer W. Kämmerer
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Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics
errNATURE REVIEWS GENETICS
IF52
err2021-06-18
err489
errOAAI
errLongo, Sophia K.; Guo, Margaret G.; Ji, Andrew L.; Khavari, Paul A.
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Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer
errCANCER DISCOVERY
IF33.3
err2023-10-17
err54
errOAAI
errSuehnholz, Sarah P.; Nissan, Moriah H.; Zhang, Hongxin; Kundra, Ritika; Nandakumar, Subhiksha; Lu, Calvin; Carrero, Stephanie; Dhaneshwar, Amanda; Fernandez, Nicole; Xu, Benjamin W.; Arcila, Maria E.; Zehir, Ahmet; Syed, Aijazuddin; Brannon, A. Rose; Rudolph, Julia E.; Paraiso, Eder; Sabbatini, Paul J.; Levine, Ross L.; Dogan, Ahmet; Gao, Jianjiong; Ladanyi, Marc; Drilon, Alexander; Berger, Michael F.; Solit, David B.; Schultz, Nikolaus; Chakravarty, Debyani
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Complications of cerebral angiography: a prospective analysis of 2,924 consecutive procedures
errNeuroradiology
IF0
err2007-06-27
err0
PREAI
errA. A. Dawkins; A. L. Evans; J. Wattam; C. A. J. Romanowski; D. J. A. Connolly; T. J. Hodgson; S. C. Coley
errShare
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