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Anticlustering for sample allocation to minimize batch effects
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DOI：10.1016/j.crmeth.2025.101137.png)
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Abstract
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• Anticlustering balances sample covariates across batches • Supports both categorical and numeric variables for flexible batch design • Must-link feature keeps related samples grouped in the same batch • Outperforms existing tools in simulations from a real-world example
Keywords:
batch effects
sample allocation
high-throughput sequencing
anticlustering
must-link constraints
sample assignment
experimental design
CP: Computational biology
CP: Systems biology
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