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Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity
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DOI：10.1126/science.adx6053.png)
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Abstract
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Bacteria, plant, and animal cells modify nucleic acids by incorporating chemical analogs of standard nucleobases. Queuine and other 7-deazapurine nucleobase analogs are commonly incorporated into tRNA and are nucleic acid modifications required for the regulation of cellular gene expression. Wassarman et al. discovered that bacterial antiphage defense enzymes can also attach 7-deazapurines to proteins, generating an N-terminal 7-amido-7-deazaguanine (NDG) modification through a conjugation reaction. Structures of the enzymes involved in this process reveal homology to canonical queuine biosynthetic enzymes and explain how NDG is attached to proteins to control immune activation. —Di Jiang
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