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Philip J. Kranzusch

harvard medical school

47H-index
154Paper Count
1.1WCitation Count
Published Papers 45
Publication Date
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Shared principles of human and bacterial antiviral immunity
errNature
IF48.5
err2026-08-12
err0
PREAI
errPhilip J. Kranzusch
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Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING
errImmunity
IF26.3
err2026-07-17
err0
errOAAI
errStephanie A. Ragland; Katherine E. Lindblad; Yao Li; Joon H. Choi; Daniel Okin; Joshua Q. Mao; Desmond Richmond-Buccola; Daniela R. Coronado; Madison R. Brown; Scott B. Snapper; Philip J. Kranzusch; Jonathan C. Kagan
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Functional diversity of phage sponge proteins that sequester host immune signals
errNature Microbiology
IF19.4
err2026-06-02
err0
PREAI
errRomi Hadary; Renee B. Chang; Nathalie Béchon; Nitzan Tal; Ilya Osterman; Erez Yirmiya; Jeremy Garb; Miguel López Rivera; Gil Amitai; Philip J. Kranzusch; Rotem Sorek
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Nuclease–NTPase antiphage defence systems use conserved molecular features to control bacterial immunity
errNature Microbiology
IF19.4
err2026-04-27
err0
PREAI
errAdelyn E. Ragucci; Sadie P. Antine; Ethan M. Leviss; Sarah E. Mooney; Jasmine M. Garcia; Lena Shyrokova; Vasili Hauryliuk; Amy S. Y. Lee; Philip J. Kranzusch
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Structural basis of QueC-family protein function in qatABCD anti-phage defense
errNature Communications
IF15.7
err2026-04-20
err0
errOAAI
errAngela Gao; Douglas R. Wassarman; Philip J. Kranzusch
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errSave
Structural modeling reveals phage proteins that manipulate bacterial immune signaling
errScience
IF45.8
err2026-03-05
err0
PREAI
errNitzan Tal; Romi Hadary; Renee B. Chang; Ilya Osterman; Roy Jacobson; Erez Yirmiya; Nathalie Bechon; Dina Hochhauser; Miguel López Rivera; Barak Madhala; Jeremy Garb; Moshe Goldsmith; Tanita Wein; Philip J. Kranzusch; Gil Amitai; Rotem Sorek
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errSave
Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly
errCell
IF42.5
err2025-12-29
err0
errOAAI
errZishuo Yu; Pradeep Sathyanarayana; Cong Liu; Joel M.J. Tan; Pan Yang; Biswajit Das; Side Hu; Xiaoyi Fan; Chenggong Ji; Sandra K. Weller; Mrinal Shekhar; Donald M. Coen; Philip J. Kranzusch; Joseph J. Loparo; Jonathan Abraham
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Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity
errScience
IF45.8
err2025-09-25
err0
errOAAI
errDouglas R. Wassarman; Patrick Pfaff; Joao A. Paulo; Steven P. Gygi; Kevan M. Shokat; Philip J. Kranzusch
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A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense
errMolecular Cell
IF16.6
err2025-08-21
err0
PREAI
errRenee B. Chang; Hunter C. Toyoda; Samuel J. Hobbs; Romi Hadary; Desmond Richmond-Buccola; Tanita Wein; Ilya Osterman; Nils Burger; Edward T. Chouchani; Rotem Sorek; Philip J. Kranzusch
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errSave
TIR domains produce histidine-ADPR as an immune signal in bacteria
errNATURE
IF48.5
err2025-04-30
err0
PREAI
errSabonis, Dziugas; Avraham, Carmel; Chang, Renee B.; Lu, Allen; Herbst, Ehud; Silanskas, Arunas; Vilutis, Deividas; Leavitt, Azita; Yirmiya, Erez; Toyoda, Hunter C.; Ruksenaite, Audrone; Zaremba, Mindaugas; Osterman, Ilya; Amitai, Gil; Kranzusch, Philip J.; Sorek, Rotem; Tamulaitiene, Giedre
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Structure-guided discovery of viral proteins that inhibit host immunity
errCELL
IF42.5
err2025-01-01
err0
PREAI
errYirmiya, Erez; Hobbs, Samuel J.; Leavitt, Azita; Osterman, Ilya; Avraham, Carmel; Hochhauser, Dina; Madhala, Barak; Skovorodka, Marharyta; Tan, Joel M. J.; Toyoda, Hunter C.; Chebotar, Igor; Itkin, Maxim; Malitsky, Sergey; Amitai, Gil; Kranzusch, Philip J.; Sorek, Rotem
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Editorial overview: Evolution of antiviral defense
errCURRENT OPINION IN MICROBIOLOGY
IF7.5
err2023-10-01
err3
PREAI
errKranzusch, Philip J.
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errSave
Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-09-27
err5
errOAAI
errBrogan, Anna P.; Habib, Cameron; Hobbs, Samuel J.; Kranzusch, Philip J.; Rudner, David Z.
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errSave
RNase L-activating 2′-5′ oligoadenylates bind ABCF1, ABCF3 and Decr-1
errJOURNAL OF GENERAL VIROLOGY
IF4.3
err2023-09-07
err1
PREAI
errGovande, Apurva A.; Babnis, Aleksandra W.; Urban, Christian; Habjan, Matthias; Hartmann, Rune; Kranzusch, Philip J.; Pichlmair, Andreas
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errSave
The virus-induced cyclic dinucleotide 2'3'-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila
errIMMUNITY
IF26.3
err2023-09-01
err20
errOAAI
errCai, Hua; Li, Lihua; Slavik, Kailey M.; Huang, Jingxian; Yin, Ting; Ai, Xianlong; Hedelin, Lena; Haas, Gabrielle; Xiang, Zhangmin; Yang, Yunyun; Li, Xiaoyan; Chen, Yuqiang; Wei, Ziming; Deng, Huimin; Chen, Di; Jiao, Renjie; Martins, Nelson; Meignin, Carine; Kranzusch, Philip J.; Imler, Jean-Luc
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Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity
errCELL REPORTS
IF6.9
err2023-08-01
err8
errOAAI
errBoys, Ian N.; Johnson, Alex G.; Quinlan, Meghan R.; Kranzusch, Philip J.; Elde, Nels C.
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errSave
Viral sponges sequester nucleotide signals to inactivate immunity
errTRENDS IN MICROBIOLOGY
IF14.9
err2023-06-01
err0
errOAAI
errRichmond-Buccola, Desmond; Kranzusch, Philip J.
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What bacterial cell death teaches us about life
errPLOS PATHOGENS
IF4.9
err2022-10-27
err9
errOAAI
errJohnson, Alex G.; Kranzusch, Philip J.
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Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine
errNATURE COMMUNICATIONS
IF15.7
err2022-10-11
err10
errOAAI
errKimura, Satoshi; Srisuknimit, Veerasak; McCarty, Kacie; Dedon, Peter C.; Kranzusch, Philip J.; Waldor, Matthew K.
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Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
errEMBO JOURNAL
IF8.3
err2022-06-07
err26
errOAAI
errHertzog, Jonny; Zhou, Wen; Fowler, Gerissa; Rigby, Rachel E.; Bridgeman, Anne; Blest, Henry Tw; Cursi, Chiara; Chauveau, Lise; Davenne, Tamara; Warner, Benjamin E.; Kinchington, Paul R.; Kranzusch, Philip J.; Rehwinkel, Jan
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Steven P. Gygi
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J
Jennifer A. Doudna
H-index: 149 · Papers: 672
B
Beatrice H. Hahn
H-index: 140 · Papers: 661
J
John J. Mekalanos
H-index: 126 · Papers: 379
K
Kevan M. Shokat
H-index: 115 · Papers: 740
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