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Disease Extent, Not Lesion Location, Determines Relapse Risk in Single-System Skeletal Langerhans Cell Histiocytosis
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DOI：10.1182/bloodadvances.2026020075.png)
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Abstract
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⁃ Relapse risk in single-system skeletal LCH is determined by disease extent rather than skeletal lesion location. ⁃ Diabetes insipidus is uncommon overall but occurs most frequently in patients with CNS-risk lesions, particularly with multifocal disease.
Keywords:
Langerhans cell histiocytosis (LCH)
single-system skeletal disease
multifocal bone lesions (MFB)
relapse risk
diabetes insipidus
risk stratification
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