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Epigenome-wide association studies without the need for cell-type composition
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DOI：10.1038/NMETH.2815.png)
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Abstract
En 中文
In epigenome-wide association studies, cell-type composition often differs between cases and controls, yielding associations that simply tag cell type rather than reveal fundamental biology. Current solutions require actual or estimated cell-type composition-information not easily obtainable for many samples of interest. We propose a method, FaST-LMM-EWASher, that automatically corrects for cell-type composition without the need for explicit knowledge of it, and then validate our method by comparison with the state-of-the-art approach.
Keywords:
LINEAR MIXED MODELS
DNA METHYLATION
GENOMIC CONTROL
RECEPTOR
CANCER
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