.png){kind=icon}
Return
Multi-slice spatial transcriptome domain analysis with SpaDo
.png){kind=icon}
OA
AI
DOI：10.1186/s13059-024-03213-x.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
With the rapid advancements in spatial transcriptome sequencing, multiple tissue slices are now available, enabling the integration and interpretation of spatial cellular landscapes. Herein, we introduce SpaDo, a tool for multi-slice spatial domain analysis, including modules for multi-slice spatial domain detection, reference-based annotation, and multiple slice clustering at both single-cell and spot resolutions. We demonstrate SpaDo's effectiveness with over 40 multi-slice spatial transcriptome datasets from 7 sequencing platforms. Our findings highlight SpaDo's potential to reveal novel biological insights in multi-slice spatial transcriptomes.
Keywords:
Spatial transcriptomics
Multiple slice analysis
Spatial domain detection
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
G
IF:
9.4
Papers:
6.4K
Citations:
7.3W
Organization
Cited Papers
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing cells in renal cell cancer.png)
IMMUNITYOAAI
IMMUNITYIF26.3
OAAIShareSaveShareSaveShareSaveShareSaveShareSaveShareSaveIn Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse HippocampusNEURONOAAI
NEURONIF15
OAAIShareSave
View more