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Proteoform Suite: Software for Constructing, Quantifying, and Visualizing Proteoform Families

delete2017-12-15
delete43
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OA
AI
A
Anthony J. Cesnik
M
Michael R. Shortreed
L
Leah V. Schaffer
R
Rachel A. Knoener
B
Brian L. Frey
M
Mark Scalf
S
Stefan K. Solntsev
Y
Yunxiang Dai
A
Audrey P. Gasch
L
Lloyd M. Smith *
DOI:10.1021/acs.jproteome.7b00685delete
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Abstract

Abstract

En 中文
We present an open-source, interactive program named Proteoform Suite that uses proteoform mass and intensity measurements from complex biological samples to identify and quantify proteoforms. It constructs families of proteoforms derived from the same gene, assesses proteoform function using gene ontology (GO) analysis, and enables visualization of quantified proteoform families and their changes. It is applied here to reveal systemic proteoform variations in the yeast response to salt stress.
Keywords:
proteoform
identification
quantification
visualization
modification
PTM
NeuCode
intact mass
lysine count
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Journal

Journal of Proteome Research cover
Journal of Proteome Research
IF:
3.6
Papers:
9.3K
Citations:
2.3W

Organization

U
university of wisconsin madison
Scholars:
3.8W
Papers: 2.9W
Citations: 53
University of Wisconsin System cover
University of Wisconsin System
Scholars:
6.7W
Papers: 5.8W
Citations: 382