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Reactome: a knowledge base of biologic pathways and processes

delete2007-03-16
delete525
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OA
AI
I
Imre Västrik
P
Peter D’Eustachio
E
Esther Schmidt
J
Joshi-Tope Geeta
G
Gopal Gopinath
D
David Croft
B
Bernard de Bono
M
Marc Gillespie
B
Bijay Jassal
S
Suzanna Lewis
L
Lisa Matthews
G
Guanming Wu
E
Ewan Birney
L
Lincoln Stein *
DOI:10.1186/gb-2007-8-3-r39delete
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Abstract

Abstract

En 中文
Reactome http://www.reactome.org, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.
Keywords:
INSULIN-RESISTANT
SYSTEMS BIOLOGY
PROTEIN
DATABASE
NETWORK
GENES
MODELS
BIND
TOOL
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Journal

G
Genome Biology
IF:
9.4
Papers:
6.4K
Citations:
7.3W

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