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K

K. Barry Sharpless

The Scripps Research Institute

136H-index
744Paper Count
10.8WCitation Count
Published Papers 190
Publication Date
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Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning
errNature Microbiology
IF19.4
err2026-06-30
err0
errOAAI
errIrene Lepori; Zichen Liu; Nelson Evbarunegbe; Shasha Feng; Turner P. Brown; Kishor Mane; Rachita Dash; Shivangi; Mitchell Wong; Ananya Naick; Amir George; Taijie Guo; Anil M. Shelke; K. Barry Sharpless; Jiajia Dong; Joel S. Freundlich; Wonpil Im; Anna G Green; Marcos M. Pires; M. Sloan Siegrist
errShare
errSave
Click-based determination of accumulation of molecules in Escherichia coli
errNature Communications
IF15.7
err2026-01-24
err0
errOAAI
errGeorge M. Ongwae; Zichen Liu; Shasha Feng; Mahendra D. Chordia; Rachita Dash; Yuchen He; Mohammad Sharifian Gh; Brianna E. Dalesandro; Taijie Guo; Karl Barry Sharpless; Jiajia Dong; M. Sloan Siegrist; Wonpil Im; Marcos M. Pires
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errSave
Alkyl sulfonyl fluorides as ambiphiles in the stereoselective palladium(II)-catalysed cyclopropanation of unactivated alkenes
errNature Synthesis
IF20
err2025-12-16
err0
errOAAI
errYilin Cao; Warabhorn Rodphon; Turki M. Alturaifi; Al Vicente Riano D. Lisboa; Zhouyang Ren; Job J. C. Struijs; Hui-Qi Ni; Taras Savchuk; Richard P. Loach; Shouliang Yang; Indrawan J. McAlpine; Donna G. Blackmond; Pavel K. Mykhailiuk; Peng Liu; K. Barry Sharpless; Keary M. Engle
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errSave
The Ionizing Zwitterionic Oxime Antidote Attenuates Gliosis in Mice Exposed to Sarin
errChemico-Biological Interactions
IF5.4
err2025-09-30
err0
PREAI
errNikolina Maček Hrvat; Borna Puljko; Rakesh K. Sit; Katarina Ilić; Dora Kolić; Kristina Mlinac-Jerkovic; Svjetlana Kalanj-Bognar; Zoran Radić; Barry K. Sharpless; Palmer Taylor; Zrinka Kovarik
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errSave
SuFEx-based antitubercular compound irreversibly inhibits Pks13
errNature
IF48.5
err2025-07-30
err0
PREAI
errInna V. Krieger; Paridhi Sukheja; Baiyuan Yang; Su Tang; Daniel Selle; Ashley Woods; Curtis Engelhart; Pradeep Kumar; Michael B. Harbut; Dongdong Liu; Brendan Tsuda; Bo Qin; Grant A. L. Bare; Gencheng Li; Victor Chi; Julian Gambacurta; Janine Hvizdos; Matthew Reagan; Isabelle L. Jones; Lisa M. Massoudi; Lisa K. Woolhiser; Alessandro Cascioferro; Erica Kundrick; Parul Singh; William Reiley; Thomas R. Ioerger; Dilipkumar Reddy Kandula; Jacob W. McCabe; Taijie Guo; David Alland; Helena I. Boshoff; Dirk Schnappinger; Gregory T. Robertson; Khisi Mdluli; Kyoung-Jin Lee; Jiajia Dong; Shuangwei Li; Peter G. Schultz; Sean B. Joseph; Melissa S. Love; K. Barry Sharpless; H. Michael Petrassi; Arnab K. Chatterjee; James C. Sacchettini; Case W. McNamara
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errSave
Click Chemistry: The Certainty of Chance (Nobel Lecture)
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2025-03-20
err1
PREAI
errSharpless, K. Barry; Finn, M. G.; Kolb, Hartmuth C.
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errSave
Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx- enabled highthroughput medicinal chemistry
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-05-16
err2
PREAI
errKitamura, Seiya; Lin, Ting Hui; Lee, Chang Chun David; Takamura, Akihiro; Kadam, Rameshwar U.; Zhang, Ding; Zhu, Xueyong; Dada, Lucas; Nagai, Emiko; Yu, Wenli; Yao, Yao; Sharpless, K. Barry; Wilson, Ian A.; Wolan, Dennis W.
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errSave
SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues
errBIOORGANIC & MEDICINAL CHEMISTRY
IF3
err2024-04-01
err3
errOAAI
errCarter, Trever R.; Milosevich, Natalia; Dada, Lucas; Shaum, James B.; Sharpless, K. Barry; Kitamura, Seiya; Erb, Michael A.
errShare
errSave
Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition
errCELL CHEMICAL BIOLOGY
IF7.2
err2024-03-01
err6
errOAAI
errMcfadden, William M.; Casey-Moore, Mary C.; Bare, Grant A. L.; Kirby, Karen A.; Wen, Xin; Li, Gencheng; Wang, Hua; Slack, Ryan L.; Snyder, Alexa A.; Lorson, Zachary C.; Kaufman, Isabella L.; Cilento, Maria E.; Tedbury, Philip R.; Gembicky, Milan; Olson, Arthur J.; Torbett, Bruce E.; Sharpless, Barry; Sarafianos, Stefan G.
errShare
errSave
Phosphorus fluoride exchange: Multidimensional catalytic click chemistry from phosphorus connective hubs
errCHEM
IF19.6
err2023-08-01
err18
errOAAI
errSun, Shoujun; Homer, Joshua A.; Smedley, Christopher J.; Cheng, Qing-Qing; Sharpless, K. Barry; Moses, John E.
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errSave
Affinity selection of double-click triazole libraries for rapid discovery of allosteric modulators for GLP-1 receptor
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-03-09
err6
errOAAI
errXin, Ye; Liu, Shuo; Liu, Yan; Qian, Zhen; Liu, Hongyue; Zhang, Bingjie; Guo, Taijie; Thompson, Garth J.; Stevens, Raymond C.; Sharpless, K. Barry; Dong, Jiajia; Shui, Wenqing
errShare
errSave
High-performing polysulfate dielectrics for electrostatic energy under harsh conditions
errJOULE
IF35.4
err2023-01-01
err66
errOAAI
errLi, He; Chang, Boyce S.; Kim, Hyunseok; Xie, Zongliang; Laine, Antione; Ma, Le; Xu, Tianlei; Yang, Chongqing; Kwon, Junpyo; Shelton, Steve W.; Klivansky, Liana M.; Altoe, Virginia; Gao, Bing; Schwartzberg, Adam M.; Peng, Zongren; Ritchie, Robert O.; Xu, Ting; Salmeron, Miquel; Ruiz, Ricardo; Sharpless, K. Barry; Wu, Peng; Liu, Yi
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errSave
Diversity oriented clicking delivers ?-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors br
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2022-09-07
err22
errOAAI
errCheng, Yunfei; Li, Gencheng; Smedley, Christopher J.; Giel, Marie -Claire; Kitamura, Seiya; Woehl, Jordan L.; Bianco, Giulia; Forli, Stefano; Homer, Joshua A.; Cappiello, John R.; Wolan, Dennis W.; Moses, John E.; Sharpless, K. Barry
errShare
errSave
Click chemistry connections for functional discovery
errNATURE SYNTHESIS
IF20
err2022-01-12
err35
errOAAI
errFinn, M. G.; Kolb, Hartmuth C.; Sharpless, K. Barry
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errSave
Chain-Growth Sulfur(VI) Fluoride Exchange Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates
errACS CENTRAL SCIENCE
IF10.4
err2021-11-03
err22
errOAAI
errKim, Hyunseok; Zhao, Jiayu; Bae, Jinhye; Klivansky, Liana M.; Dailing, Eric A.; Liu, Yi; Cappiello, John R.; Sharpless, K. Barry; Wu, Peng
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errSave
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2021-08-18
err20
errOAAI
errSun, Shoujun; Gao, Bing; Chen, Junyu; Sharpless, K. Barry; Dong, Jiajia
errShare
errSave
SuFExable polymers with helical structures derived from thionyl tetrafluoride
errNATURE CHEMISTRY
IF20.2
err2021-08-16
err96
errOAAI
errLi, Suhua; Li, Gencheng; Gao, Bing; Pujari, Sidharam P.; Chen, Xiaoyan; Kim, Hyunseok; Zhou, Feng; Klivansky, Liana M.; Liu, Yi; Driss, Hafedh; Liang, Dong-Dong; Lu, Jianmei; Wu, Peng; Zuilhof, Han; Moses, John; Sharpless, K. Barry
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errSave
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-07-09
err36
errOAAI
errZhang, Jiong; Zhao, Xiangxiang; Cappiello, John R.; Yang, Yi; Cheng, Yunfei; Liu, Guang; Fang, Wenjing; Luo, Yinzhu; Zhang, Yu; Dong, Jiajia; Zhang, Lixin; Sharpless, K. Barry
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errSave
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia
errACS CENTRAL SCIENCE
IF10.4
err2021-04-30
err57
errOAAI
errGarnar-Wortzel, Leopold; Bishop, Timothy R.; Kitamura, Seiya; Milosevich, Natalia; Asiaban, Joshua N.; Zhang, Xiaoyu; Zheng, Qinheng; Chen, Emily; Ramos, Anissa R.; Ackerman, Christopher J.; Hampton, Eric N.; Chatterjee, Arnab K.; Young, Travis S.; Hull, Mitchell, V; Sharpless, K. Barry; Cravatt, Benjamin F.; Wolan, Dennis W.; Erb, Michael A.
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errSave
Sulfur [18F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2021-02-25
err107
errOAAI
errZheng, Qinheng; Xu, Hongtao; Wang, Hua; Du, Wen-Ge Han; Wang, Nan; Xiong, Huan; Gu, Yuang; Noodleman, Louis; Sharpless, K. Barry; Yang, Guang; Wu, Peng
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
I
Ian A. Wilson
H-index: 179 · Papers: 1.7K
M
Matthias Beller
H-index: 174 · Papers: 2.2K
P
Peter G. Schultz
H-index: 159 · Papers: 880
B
Benjamin F. Cravatt
H-index: 148 · Papers: 866
R
Robert O. Ritchie
H-index: 147 · Papers: 1.0K
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