Not logged inBRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression
Schuetze, KB; Stratton, MS; Bagchi, RA; Hobby, ARH; Felisbino, MB; Rubino, M; Toni, LS; Reges, C; Cavasin, MA; Mcmahan, RH; Alexanian, M; Vagnozzi, RJ; Mckinsey, TA .png)
Share.png)
SaveChromatin Remodeling Drives Immune-Fibroblast Cell Communication in Heart FailureAlexanian, Michael; Padmanabhan, Arun; Nishino, Tomohiro; Travers, Joshua; Ye, Lin; Angelo, Pelonero; Lee, Clara; Sadagopan, Nandhini; Huang, Yu; Auclair, Kirsten; Zhu, Ada; An, Yuqian; Ekstrand, Christina; Martinez, Cassandra; Teran, Barbara Gonzalez; Flanigan, Will; Kim, Charis Kee-Seon; Conradson, Devon; Gardner, Zachary; Li, Li; Costa, Mauro; Jain, Rajan; Charo, Israel; Combes, Alexis; Haldar, Saptarsi; Pollard, Katherine; Vagnozzi, Ronald; McKinsey, Timothy; Przytycki, Pawel; Srivastava, Deepak Share Save A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiationPadmanabhan, Arun; de Soysa, T. Yvanka; Pelonero, Angelo; Sapp, Valerie; Shah, Parisha P.; Wang, Qiaohong; Li, Li; Lee, Clara Youngna; Sadagopan, Nandhini; Nishino, Tomohiro; Ye, Lin; Yang, Rachel; Karnay, Ashley; Poleshko, Andrey; Bolar, Nikhita; Linares-Saldana, Ricardo; Ranade, Sanjeev S.; Alexanian, Michael; Morton, Sarah U.; Jain, Mohit; Haldar, Saptarsi M.; Srivastava, Deepak; Jain, Rajan Share Save Single-cell multimodal analyses reveal epigenomic and transcriptomic basis for birth defects in maternal diabetesNishino, Tomohiro; Ranade, Sanjeev S.; Pelonero, Angelo; van Soldt, Benjamin J.; Ye, Lin; Alexanian, Michael; Koback, Frances; Huang, Yu; Wallace, Langley Grace; Sadagopan, Nandhini; Lam, Adrienne; Zholudeva, Lyandysha V.; Li, Feiya; Padmanabhan, Arun; Thomas, Reuben; van Bemmel, Joke G.; Gifford, Casey A.; Costa, Mauro W.; Srivastava, Deepak Share Save Share Save Share Save Targeting transcription in heart failure via CDK7/12/13 inhibitionHsu, Austin; Duan, Qiming; Day, Daniel S.; Luo, Xin; McMahon, Sarah; Huang, Yu; Feldman, Zachary B.; Jiang, Zhen; Zhang, Tinghu; Liang, Yanke; Alexanian, Michael; Padmanabhan, Arun; Brown, Jonathan D.; Lin, Charles Y.; Gray, Nathanael S.; Young, Richard A.; Bruneau, Benoit G.; Haldar, Saptarsi M. Share Save KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammationJiang, Zhen; Elsarrag, Selma Z.; Duan, Qiming; LaGory, Edward L.; Wang, Zhe; Alexanian, Michael; McMahon, Sarah; Rulifson, Ingrid C.; Winchester, Sarah; Wang, Yi; Vaisse, Christian; Brown, Jonathan D.; Quattrocelli, Mattia; Lin, Charles Y.; Haldar, Saptarsi M. Share Save BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult CardiomyocytesPadmanabhan, Arun; Alexanian, Michael; Linares-Saldana, Ricardo; Gonzalez-Teran, Barbara; Andreoletti, Gaia; Huang, Yu; Connolly, Andrew J.; Kim, Wonho; Hsu, Austin; Duan, Qiming; Winchester, Sarah A. B.; Felix, Franco; Perez-Bermejo, Juan A.; Wang, Qiaohong; Li, Li; Shah, Parisha P.; Haldar, Saptarsi M.; Jain, Rajan; Srivastava, Deepak Share Save Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell IdentityShim, Woo Jun; Sinniah, Enakshi; Xu, Jun; Vitrinel, Burcu; Alexanian, Michael; Andreoletti, Gaia; Shen, Sophie; Sun, Yuliangzi; Balderson, Brad; Boix, Carles; Peng, Guangdun; Jing, Naihe; Wang, Yuliang; Kellis, Manolis; Tam, Patrick P. L.; Smith, Aaron; Piper, Michael; Christiaen, Lionel; Quan Nguyen; Boden, Mikael; Palpant, Nathan J. Share Save Share Save Share Save Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast ActivationStratton, Matthew S.; Bagchi, Rushita A.; Felisbino, Marina B.; Hirsch, Rachel A.; Smith, Harrison E.; Riching, Andrew S.; Enyart, Blake Y.; Koch, Keith A.; Cavasin, Maria A.; Alexanian, Michael; Song, Kunhua; Qi, Jun; Lemieux, Madeleine E.; Srivastava, Deepak; Lam, Maggie P. Y.; Haldar, Saptarsi M.; Lin, Charles Y.; McKinsey, Timothy A. Share Save Share Save Share Save A transcribed enhancer dictates mesendoderm specification in pluripotencyAlexanian, Michael; Maric, Daniel; Jenkinson, Stephen P.; Mina, Marco; Friedman, Clayton E.; Ting, Ching-Chia; Micheletti, Rudi; Plaisance, Isabelle; Nemir, Mohamed; Maison, Damien; Kernen, Jasmin; Pezzuto, Iole; Villeneuve, Dominic; Burdet, Frederic; Ibberson, Mark; Leib, Stephen L.; Palpant, Nathan J.; Hernandez, Nouria; Ounzain, Samir; Pedrazzini, Thierry Share Save The long noncoding RNA Wisper controls cardiac fibrosis and remodelingMicheletti, Rudi; Plaisance, Isabelle; Abraham, Brian J.; Sarre, Alexandre; Ting, Ching-Chia; Alexanian, Michael; Maric, Daniel; Maison, Damien; Nemir, Mohamed; Young, Richard A.; Schroen, Blanche; Gonzalez, Arantxa; Ounzain, Samir; Pedrazzini, Thierry Share Save CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasisOunzain, Samir; Micheletti, Rudi; Arnan, Carme; Plaisance, Isabelle; Cecchi, Dario; Schroen, Blanche; Reverter, Ferran; Alexanian, Michael; Gonzales, Christine; Ng, Shi Yan; Bussotti, Giovanni; Pezzuto, Iole; Notredame, Cedric; Heymans, Stephane; Guigo, Roderic; Johnson, Rory; Pedrazzini, Thierry Share Save Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and diseaseOunzain, Samir; Pezzuto, Iole; Micheletti, Rudi; Burdet, Frederic; Sheta, Razan; Nemir, Mohamed; Gonzales, Christine; Sarre, Alexandre; Alexanian, Michael; Blow, Matthew J.; May, Dalit; Johnson, Rory; Dauvillier, Jerome; Pennacchio, Len A.; Pedrazzini, Thierry Share Save Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAsOunzain, Samir; Micheletti, Rudi; Beckmann, Tal; Schroen, Blanche; Alexanian, Michael; Pezzuto, Iole; Crippa, Stefania; Nemir, Mohamed; Sarre, Alexandre; Johnson, Rory; Dauvillier, Jerome; Burdet, Frederic; Ibberson, Mark; Guigo, Roderic; Xenarios, Ioannis; Heymans, Stephane; Pedrazzini, Thierry Share Save 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
