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E

Eugene I. Shakhnovich

Harvard University

76H-index
474Paper Count
2.1WCitation Count
Published Papers 135
Publication Date
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Complete enzyme clustering enhances coenzyme Q biosynthesis via substrate channeling
errNature Communications
IF15.7
err2026-06-29
err0
errOAAI
errDianzhuo Wang; Andrea Gottinger; Jio Jeong; Callum R. Nicoll; Junlang Liu; Tereza Kadavá; Domiziana Cecchini; Marco Malatesta; Albert J. R. Heck; Andrea Mattevi; Eugene I. Shakhnovich
errShare
errSave
CASPULE: A computational tool to study sticker spacer polymer condensates
errPLoS Computational Biology
IF3.6
err2026-05-08
err1
PREAI
errChattaraj, Aniruddha; Kanovich, David S.; Ranganathan, Srivastav; Shakhnovich, Eugene I.
errShare
errSave
Origin of the ionic-strength dependent reentrant behavior in the liquid-liquid phase separation of uncharged intrinsically disordered proteins
errCommunications Chemistry
IF6.2
err2026-04-11
err0
errOAAI
errSayantan Mondal; Eugene Shakhnovich
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errSave
The Eye Lens Protein, γS Crystallin, Undergoes Glutathionylation-Induced Disulfide Bonding Between Cysteines 22 and 26
errBIOMOLECULES
IF4.8
err2025-03-11
err0
errOAAI
errHalverson-Kolkind, Kate; Thorn, David C.; Tovar-Ramirez, Martin; Shakhnovich, Eugene; David, Larry; Lampi, Kirsten
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errSave
A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A
errNATURE COMMUNICATIONS
IF15.7
err2025-02-03
err0
errOAAI
errSabbarini, Ibrahim M.; Reif, Dvir; Park, Kibum; Mcquown, Alexander J.; Nelliat, Anjali R.; Trejtnar, Charlotte; Doetsch, Volker; Shakhnovich, Eugene I.; Murray, Andrew W.; Denic, Vladimir
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errSave
Protein Quality Control is a Master Modulator of Molecular Evolution in Bacteria
errGENOME BIOLOGY AND EVOLUTION
IF2.8
err2025-01-22
err0
errOAAI
errArenas, Carolina Diaz; Alvarez, Maristella; Wilson, Robert H.; Shakhnovich, Eugene, I; Ogbunugafor, C. Brandon
errShare
errSave
Separation of sticker-spacer energetics governs the coalescence of metastable condensates
errBIOPHYSICAL JOURNAL
IF3.1
err2025-01-01
err0
errOAAI
errChattaraj, Aniruddha; Shakhnovich, Eugene I.
errShare
errSave
Multi-condensate state as a functional strategy to optimize the cell signaling output
errNATURE COMMUNICATIONS
IF15.7
err2024-07-25
err0
errOAAI
errChattaraj, Aniruddha; Shakhnovich, Eugene I.
errShare
errSave
Biophysical principles predict fitness of SARS-CoV-2 variants
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-05-31
err2
errOAAI
errWang, Dianzhuo; Huot, Marian; Mohanty, Vaibhav; Shakhnovich, Eugene I.; Sali, Andrej
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errSave
The critical role of co-translational folding: An evolutionary and biophysical perspective
errCURRENT OPINION IN SYSTEMS BIOLOGY
IF2.2
err2024-03-01
err1
errOAAI
errBitran, Amir; Jacobs, William M.; Shakhnovich, Eugene
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errSave
Enzymatic metabolons dramatically enhance metabolic fluxes of low-efficiency biochemical reactions
errBIOPHYSICAL JOURNAL
IF3.1
err2023-12-01
err1
PREAI
errRanganathan, Srivastav; Liu, Junlang; Shakhnovich, Eugene
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errSave
Mapping the Space of Photoswitchable Ligands and Photodruggable Proteins with Computational Modeling
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-09-06
err0
errOAAI
errAxelrod, Simon; Shakhnovich, Eugene; Gomez-Bombarelli, Rafael
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errSave
Co-translational formation of disulfides guides folding of the SARS-CoV-2 receptor binding domain
errBIOPHYSICAL JOURNAL
IF3.1
err2023-08-01
err1
errOAAI
errBitran, Amir; Park, Kibum; Serebryany, Eugene; Shakhnovich, Eugene I.
errShare
errSave
Empowering drug off-target discovery with metabolic and structural analysis
errNATURE COMMUNICATIONS
IF15.7
err2023-06-09
err11
errOAAI
errChowdhury, Sourav; Zielinski, Daniel C.; Dalldorf, Christopher; Rodrigues, Joao V.; Palsson, Bernhard O.; Shakhnovich, Eugene I.
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errSave
Systematic conformation-to-phenotype mapping via limited deep sequencing of proteins
errMOLECULAR CELL
IF16.6
err2023-06-01
err2
errOAAI
errSerebryany, Eugene; Zhao, Victor Y.; Park, Kibum; Bitran, Amir; Trauger, Sunia A.; Budnik, Bogdan; Shakhnovich, Eugene I.
errShare
errSave
Phosphorylation sites are evolutionary checkpoints against liquid-solid transition in protein condensates
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-05-08
err7
errOAAI
errRanganathan, Srivastav; Dasmeh, Pouria; Furniss, Seth; Shakhnovich, Eugene
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errSave
Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-04-24
err5
errOAAI
errScheerer, David; Adkar, Bharat V.; Bhattacharyya, Sanchari; Levy, Dorit; Iljina, Marija; Riven, Inbal; Dym, Orly; Haran, Gilad; Shakhnovich, Eugene I.
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errSave
Thermal Half-Lives of Azobenzene Derivatives: Virtual Screening Based on Intersystem Crossing Using a Machine Learning Potential
errACS CENTRAL SCIENCE
IF10.4
err2023-01-25
err21
errOAAI
errAxelrod, Simon; Shakhnovich, Eugene; Gomez-Bombarelli, Rafael
errShare
errSave
Different states and the associated fates of biomolecular condensates
errESSAYS IN BIOCHEMISTRY
IF5.7
err2022-12-16
err3
errOAAI
errRanganathan, Srivastav; Liu, Junlang; Shakhnovich, Eugene
errShare
errSave
The physics of liquid-to-solid transitions in multi- domain protein condensates
errBIOPHYSICAL JOURNAL
IF3.1
err2022-07-01
err25
errOAAI
errRanganathan, Srivastav; Shakhnovich, Eugene
errShare
errSave

Research Directions

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Co-authors
Cooperation Journals
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David A. Weitz
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M
Martin Karplus
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S
Stuart L. Schreiber
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