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Patrick S. Fier

Merck & Co.

26H-index
71Paper Count
3.3KCitation Count
Published Papers 32
Publication Date
N-Alkyl and N-Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors
err2026-02-24
err0
PREAI
errRohan R. Merchant; Natalia Chernyak; Jovan A. Lopez; Phillip P. Sharp; Mihir Mandal; Jiafang He; Alan Hruza; Paul Rearden; Daniel A. Tatosian; Joel Esmay; Song Yang; Alan C. Cheng; Ken Ellsworth; Aimie Ogawa; Tiffany Piou; Patrick Fier; Jacqueline Hicks; Christopher Sinz; Anthony K. Ogawa
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Reagent for the Chemoselective Reduction of Carboxylic Acids to Aldehydes
err2025-10-23
err0
PREAI
errEthan Fung; Kevin M. Maloney; Patrick S. Fier
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Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib
err2024-05-09
err1
PREAI
errFranklin, Robert D.; Armiger, Travis; Otte, Douglas A. L.; Larson, Reed T.; Spencer, Glenn; Patel, Pratiq A.; Paulines, Mellie June; Hall, Jackson R.; Xiao, Kai-Jiong; Fier, Patrick S.; Rodrigues, Vailankanni L.; Guetschow, Erik D.; Kuhl, Nadine; Jellett, Lisa; Corry, James; Chung, Cheol K.; Thaisrivongs, David A.
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Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation-Lithiation as a Batch-Flow Process
err2024-05-09
err0
PREAI
errOtte, Douglas A. L.; Larson, Reed T.; Alwedi, Embarek; Armiger, Travis; Chen, Yonggang; Chung, Cheol K.; Corry, James; Desmond, Richard; Fier, Patrick S.; Franklin, Robert D.; Guetschow, Erik D.; Hall, Jackson R.; Halsey, Holst M.; Hartmanshenn, Clara; Jellett, Lisa; Kuhl, Nadine; Levesque, Francois; McMullen, Jonathan P.; Patel, Pratiq A.; Paulines, Mellie June; Ren, Hong; Rodrigues, Vailankanni L.; Ruccolo, Serge; Tan, Lushi; Thaisrivongs, David A.; Xiao, Kai-Jiong
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Dynamic sampling in autonomous process optimization
err2024-01-01
err2
errOAAI
errChristensen, Melodie; Xu, Yuting; Kwan, Eugene E.; Di Maso, Michael J.; Ji, Yining; Reibarkh, Mikhail; Sun, Alexandra C.; Liaw, Andy; Fier, Patrick S.; Grosser, Shane; Hein, Jason E.
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Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19
err2023-10-20
err2
PREAI
errBade, Rachel; Bothe, Jameson R.; Sirota, Eric; Brunskill, Andrew P. J.; Newman, Justin A.; Zhang, Yongqian; Tan, Melissa; Zheng, Michelle; Brito, Gilmar; Poirier, Marc; Fier, Patrick S.; Xu, Yingju; Ward, Michael D.; Stone, Kevin; Lee, Ivan H.; Gmitter, Andrew J.; Bernardoni, Frank; Zompa, Michael A.; Luo, Hanlin; Patel, Sanjaykumar; Masiuk, Tina; Mora, Jeff; Ni, Tong; Okoh, Grace A.; Tarabokija, James; Liu, Jiaying; Lowinger, Michael B.; Mahmood, Tariq
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The Direct Conversion of Esters to Ketones Enabled by a Traceless Activating Group
err2023-04-26
err4
PREAI
errFier, Patrick S.; Roberts, Riley A.; Larson, Reed T.
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Diverse Catalytic Reactions for the Stereoselective Synthesis ofCyclic Dinucleotide MK-1454
err2022-03-25
err30
PREAI
errBenkovics, Tamas; Peng, Feng; Phillips, Eric M.; An, Chihui; Bade, Rachel S.; Chung, Cheol K.; Dance, Zachary E. X.; Fier, Patrick S.; Forstater, Jacob H.; Liu, Zhijian; Liu, Zhuqing; Maligres, Peter E.; Marshall, Nicholas M.; Marzijarani, Nastaran Salehi; McIntosh, John A.; Miller, Steven P.; Moore, Jeffrey C.; Neel, Andrew J.; Obligacion, Jennifer, V; Pan, Weilan; Pirnot, Michael T.; Poirier, Marc; Reibarkh, Mikhail; Sherry, Benjamin D.; Song, Zhiguo Jake; Tan, Lushi; Turnbull, Ben W. H.; Verma, Deeptak; Waldman, Jacob H.; Wang, Lu; Wang, Tao; Winston, Matthew S.; Xu, Feng
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Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19
err2021-12-10
err24
PREAI
errFier, Patrick S.; Xu, Yingju; Poirier, Marc; Brito, Gilmar; Zheng, Michelle; Bade, Rachel; Sirota, Eric; Stone, Kevin; Tan, Lushi; Humphrey, Guy R.; Chang, Darryl; Bothe, Jameson; Zhang, Yongqian; Bernardoni, Frank; Castro, Steve; Zompa, Michael A.; Taylor, Jerry; Sirk, Kevin M.; Diaz-Santana, Anthony; Diribe, Ike; Emerson, Khateeta M.; Krishnamurthi, Bharath; Zhao, Ralph; Ward, Michael; Xiao, Chengqian; Ouyand, Honggui; Zhan, Jianfeng; Morris, William J.
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Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19
err2021-10-29
err109
errOAAI
errMcIntosh, John A.; Benkovics, Tamas; Silverman, Steven M.; Huffman, Mark A.; Kong, Jongrock; Maligres, Peter E.; Itoh, Tetsuji; Yang, Hao; Verma, Deeptak; Pan, Weilan; Ho, Hsing-, I; Vroom, Jonathan; Knight, Anders M.; Hurtak, Jessica A.; Klapars, Artis; Fryszkowska, Anna; Morris, William J.; Strotman, Neil A.; Murphy, Grant S.; Maloney, Kevin M.; Fier, Patrick S.
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Development of a Practical Manufacturing Process to Relebactam via Thorough Understanding of the Origin and Control of Oligomeric Impurities
err2021-09-13
err2
PREAI
errKim, Jungchul; Itoh, Tetsuji; Xu, Feng; Dance, Zachary E. X.; Waldman, Jacob H.; Wallace, Debra J.; Wu, Feiyue; Kats-Kagan, Roman; Ekkati, Anil R.; Brunskill, Andrew P. J.; Peng, Feng; Fier, Patrick S.; Obligacion, Jennifer, V; Sherry, Benjamin D.; Liu, Zhijian; Emerson, Khateeta M.; Fine, Adam J.; Jenks, Anna, V; Armenante, Marco Euclide
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The application of modern reactions in large-scale synthesis
err2021-06-22
err58
PREAI
errLovato, Kaitlyn; Fier, Patrick S.; Maloney, Kevin M.
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The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer
err2021-03-23
err20
PREAI
errQuiroz, Ryan, V; Reutershan, Michael H.; Schneider, Sebastian E.; Sloman, David; Lacey, Brian M.; Swalm, Brooke M.; Yeung, Charles S.; Gibeau, Craig; Spellman, Daniel S.; Rankic, Danica A.; Chen, Dapeng; Witter, David; Linn, Doug; Munsell, Erik; Feng, Guo; Xu, Haiyan; Hughes, Jonathan M. E.; Lim, Jongwon; Sauri, Josep; Geddes, Kristin; Wan, Murray; Mansueto, My Sam; Follmer, Nicole E.; Fier, Patrick S.; Siliphaivanh, Phieng; Daublain, Pierre; Palte, Rachel L.; Hayes, Robert P.; Lee, Sandra; Kawamura, Shuhei; Silverman, Steven; Sanyal, Sulagna; Henderson, Timothy J.; Ye, Yingchun; Gao, Yuanwei; Nicholson, Benjamin; Machacek, Michelle R.
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Late-Stage 18O Labeling of Primary Sulfonamides via a Degradation-Reconstruction Pathway
err2020-03-05
err12
PREAI
errReilly, Sean W.; Bennett, Frank; Fier, Patrick S.; Ren, Sumei; Strotman, Neil A.
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