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J

Jacob Witten

case western reserve university

15H-index
34Paper Count
1.2KCitation Count
Published Papers 20
Publication Date
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Progress and challenges in cystic fibrosis gene editing
errJournal of Cystic Fibrosis
IF6
err2026-05-12
err0
errOAAI
errJacob Witten; Marie Egan; Anna Cereseto
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errSave
Lipid Nanoparticle Database towards structure-function modeling and data-driven design for nucleic acid delivery
errNature Communications
IF15.7
err2026-01-28
err0
errOAAI
errEvan Collins; Jungyong Ji; Sung-Gwang Kim; Jacob Witten; Seonghoon Kim; Richard Zhu; Peter Park; Minjun Jung; Aron Park; Rajith S. Manan; Arnab Rudra; Gyochang Keum; Eun-Kyoung Bang; Jun-O Jin; William J. Jeang; Robert Langer; Daniel G. Anderson; Wonpil Im
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errSave
Biotechnology in materials science: A storied past and a bold future
errMRS Bulletin
IF4.9
err2025-09-11
err0
errOAAI
errShonit Nair Sharma; Jacob Witten; Rishi Das; R. Rox Anderson; Daniel G. Anderson; Robert Langer
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errSave
NumSimEX: A method using EXX hydrogen exchange mass spectrometry to map the energetics of protein folding landscapes
errPROTEIN SCIENCE
IF5.2
err2025-01-25
err0
errOAAI
errFlint, Jasper A. G.; Witten, Jacob; Han, Isabella; Strahan, John; Damjanovic, Jovan; Song, Nevon; Poterba, Tim; Cartagena, Alexis Jaramillo; Hirsch, Angelika; Ni, Tony; Sohl, Julie L.; Wagaman, Amy S.; Jaswal, Sheila S.
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Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy
errNATURE BIOTECHNOLOGY
IF41.7
err2024-12-10
err0
PREAI
errWitten, Jacob; Raji, Idris; Manan, Rajith S.; Beyer, Emily; Bartlett, Sandra; Tang, Yinghua; Ebadi, Mehrnoosh; Lei, Junying; Nguyen, Dien; Oladimeji, Favour; Jiang, Allen Yujie; Macdonald, Elise; Hu, Yizong; Mughal, Haseeb; Self, Ava; Collins, Evan; Yan, Ziying; Engelhardt, John F.; Langer, Robert; Anderson, Daniel G.
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Zwitterionic Polymer-Functionalized Lipid Nanoparticles for the Nebulized Delivery of mRNA
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-11-13
err0
PREAI
errJiang, Allen Y.; Lathwal, Sushil; Meng, Sabrina; Witten, Jacob; Beyer, Emily; Mcmullen, Patrick; Hu, Yizong; Manan, Rajith S.; Raji, Idris; Langer, Robert; Anderson, Daniel G.
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errSave
Inhalable Dry Powders for Lung mRNA Delivery
errADVANCED HEALTHCARE MATERIALS
IF9.6
err2024-10-01
err0
errOAAI
errGordon, Akiva; Li, Bowen; Witten, Jacob; Nguyen, Hong; Anderson, Daniel G.
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errSave
Recent advances in nanoparticulate RNA delivery systems
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-03-04
err23
errOAAI
errWitten, Jacob; Hu, Yizong; Langer, Robert; Anderson, Daniel G.
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errSave
Combinatorial development of nebulized mRNA delivery formulations for the lungs
errNATURE NANOTECHNOLOGY
IF34.9
err2023-11-20
err32
errOAAI
errJiang, Allen Y.; Witten, Jacob; Raji, Idris O.; Eweje, Feyisayo; Macisaac, Corina; Meng, Sabrina; Oladimeji, Favour A.; Hu, Yizong; Manan, Rajith S.; Langer, Robert; Anderson, Daniel G.
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Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA
errNATURE BIOMEDICAL ENGINEERING
IF26.6
err2023-09-07
err52
PREAI
errLi, Bowen; Jiang, Allen Yujie; Raji, Idris; Atyeo, Caroline; Raimondo, Theresa M.; Gordon, Akiva G. R.; Rhym, Luke H.; Samad, Tahoura; Macisaac, Corina; Witten, Jacob; Mughal, Haseeb; Chicz, Taras M.; Xu, Yue; Mcnamara, Ryan P.; Bhatia, Sangeeta; Alter, Galit; Langer, Robert; Anderson, Daniel G.
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errSave
Comparison of Physicochemical Properties of Native Mucus and Reconstituted Mucin Gels
errBIOMACROMOLECULES
IF5.4
err2023-02-02
err21
errOAAI
errWagner, Caroline E.; Krupkin, Miri; Smith-Dupont, Kathryn B.; Wu, Chloe M.; Bustos, Nicole A.; Witten, Jacob; Ribbeck, Katharina
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errSave
Spatial configuration of charge and hydrophobicity tune particle transport through mucus
errBIOPHYSICAL JOURNAL
IF3.1
err2022-01-01
err7
errOAAI
errSamad, Tahoura; Witten, Jacob; Grodzinsky, Alan J.; Ribbeck, Katharina
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errSave
Computational Insights into Avidity of Polymeric Multivalent Binders
errBIOPHYSICAL JOURNAL
IF3.1
err2019-09-01
err15
errOAAI
errZumbro, Emiko; Witten, Jacob; Alexander-Katz, Alfredo
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errSave
Mucus and Mucin Environments Reduce the Efficacy of Polymyxin and Fluoroquinolone Antibiotics against Pseudomonas aeruginosa
errACS BIOMATERIALS SCIENCE & ENGINEERING
IF5.5
err2019-02-22
err36
errOAAI
errSamad, Tahoura; Co, Julia Y.; Witten, Jacob; Ribbeck, Katharina
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errSave
Molecular Characterization of Mucus Binding
errBIOMACROMOLECULES
IF5.4
err2019-02-19
err34
errOAAI
errWitten, Jacob; Samad, Tahoura; Ribbeck, Katharina
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errSave
Selective permeability of mucus barriers
errCURRENT OPINION IN BIOTECHNOLOGY
IF7
err2018-08-01
err120
errOAAI
errWitten, Jacob; Samad, Tahoura; Ribbeck, Katharina
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errSave
Charge Influences Substrate Recognition and Self-Assembly of Hydrophobic FG Sequences
errBIOPHYSICAL JOURNAL
IF3.1
err2017-11-01
err9
errOAAI
errChen, Wesley G.; Witten, Jacob; Grindy, Scott C.; Holten-Andersen, Niels; Ribbeck, Katharina
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errSave
Probing the potential of mucus permeability to signify preterm birth risk
errSCIENTIFIC REPORTS
IF3.9
err2017-09-04
err28
errOAAI
errSmith-Dupont, K. B.; Wagner, C. E.; Witten, J.; Conroy, K.; Rudoltz, H.; Pagidas, K.; Snegovskikh, V.; House, M.; Ribbeck, K.
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errSave
The particle in the spider's web: transport through biological hydrogels
errNANOSCALE
IF5.1
err2017-01-01
err129
errOAAI
errWitten, Jacob; Ribbeck, Katharina
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errSave
Preparation of two novel monobrominated 2-(2′,4′-dihydroxybenzoyl)-3,4,5,6-tetrachlorobenzoic acids and their separation from crude synthetic mixtures using vortex counter-current chromatography
errJOURNAL OF CHROMATOGRAPHY A
IF4
err2012-05-01
err12
errOAAI
errWeisz, Adrian; Witten, Jacob J.; Zeng, Yun; Mazzola, Eugene P.; Ito, Yoichiro
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
R
Róbert Langer
H-index: 262 · Papers: 2.0K
D
Daniel G. Anderson
H-index: 128 · Papers: 470
G
Galit Alter
H-index: 113 · Papers: 629
S
Sangeeta N. Bhatia
H-index: 111 · Papers: 524
A
Alan J. Grodzinsky
H-index: 98 · Papers: 498
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