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Thomas C. Irving

illinois institute of technology

52H-index
366Paper Count
1.0WCitation Count
Published Papers 141
Publication Date
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Kbtbd13 knockdown restores muscle function in a clinically relevant mouse model of nemaline myopathy type 6
errScience Translational Medicine
IF14.6
err2026-06-24
err0
PREAI
errRicardo A. Galli; Leander A. Vonk; Rianne J. Baelde; Anita van den Heuvel; Sylvia Bogaards; Stefan Conijn; Emma Siteur; Olga Alekhina; Henk Granzier; Thomas Irving; Weikang Ma; Karlijn Bouman; Baziel van Engelen; Silvère M. van der Maarel; Tyler J. Kirby; Nicol Voermans; Josine de Winter; Coen A.C. Ottenheijm
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Severe obesity in human HFpEF alters contractile protein function and organization
errScience
IF45.8
err2026-04-23
err0
PREAI
errVivek P. Jani; Marcus Rhodehamel; Axel J. Fenwick; Weikang Ma; Eli Fisher; Maria T. Giannakopoulos; Sun Moon; Romi L. Castillo; Leslie M. Kennedy; Thomas C. Irving; Jil C. Tardiff; Elizabeth Murphy; Raghothama Chaerkady; Qing Wang; Meaghan E. Barry; Virginia S. Hahn; Kavita Sharma; Kenneth B. Margulies; Kenneth C. Bedi; Anthony Cammarato; David A. Kass
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Comparison of Predicted X-Ray Fiber Diffraction Patterns from All-Atom and Coarse-Grained Actin Filament Models Under Nonuniform Strain
errInternational Journal of Molecular Sciences
IF4.9
err2026-03-04
err0
errOAAI
errMomcilo Prodanovic; Andjela Kafedziski; Thomas C. Irving; Srboljub M. Mijailovich
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Myosin Modulator Aficamten Inhibits Force by Altering Myosin's Biochemical Activity Without Changing Thick Filament Structure
errJACC-BASIC TO TRANSLATIONAL SCIENCE
IF7.2
err2026-01-01
err0
errOAAI
errMohran, Saffie; Kooiker, Kristina B.; Naim, Ateeqa; Pilagov, Matvey; Asencio, Anthony; Turner, Kyrah L.; Ma, Weikang; Flint, Galina; Jiang, Siyao; Zhao, Jing; Mcmillen, Timothy S.; Mandrycky, Christian; Mahoney-Schaefer, Max; Irving, Thomas C.; Tanner, Bertrand C. W.; Kad, Neil M.; Regnier, Michael; Moussavi-Harami, Farid
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MuscleX-DI: an integrated data analysis package for X-ray scanning diffraction imaging experiments
errJournal of Synchrotron Radiation
IF3
err2026-01-01
err0
PREAI
errMadhurapantula, Rama S.; Jiratrakanvong, Jiranun; Nikseresht, Grant; Miskin, Nikhil; Huo, Ran; Nabon, Jules; Irving, Thomas C.; Agam, Gady; Orgel, Joseph
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Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed mouse skeletal muscle
errPHYSIOLOGICAL REPORTS
IF1.9
err2025-10-27
err0
errOAAI
errKuehn, Michel N.; Engels, Nichlas M.; Nissen, Devin L.; Freundt, Johanna K.; Ma, Weikang; Harris, Samantha P.; Irving, Thomas C.; Linke, Wolfgang A.; Hessel, Anthony L.
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Annotating the X-ray diffraction pattern of vertebrate striated muscle
errBiophysical Journal
IF3.1
err2025-09-15
err0
errOAAI
errNatalia A. Koubassova; Debabrata Dutta; Weikang Ma; Andrey K. Tsaturyan; Thomas Irving; Raúl Padrón; Roger Craig
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errSave
Calcium has a direct effect on thick filament activation in porcine myocardium
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-09-20
err2
errOAAI
errMohran, Saffie; McMillen, Timothy S.; Mandrycky, Christian; Tu, An-Yue; Kooiker, Kristina B.; Qian, Wenjing; Neys, Stephanie; Osegueda, Brayan; Moussavi-Harami, Farid; Irving, Thomas C.; Regnier, Michael; Ma, Weikang
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Mechanisms of a novel regulatory light chain-dependent cardiac myosin inhibitor
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-07-31
err1
PREAI
errKooiker, Kristina; Gan, Qing-Fen; Yu, Ming; Sa, Na; Mohran, Saffie; Cheng, Yuanhua; Flint, Galina; Neys, Stephanie; Gao, Chengqian; Nissen, Devin; McMillen, Tim; Asencio, Anthony; Ma, Weikang; Irving, Thomas C.; Moussavi-Harami, Farid; Regnier, Michael
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errSave
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2024-07-31
err0
PREAI
errvan den Berg, Marloes; Shi, Zhonghua; Claassen, Wout J.; Hooijman, Pleuni; Lewis, Christopher T. A.; Andersen, Jesper L.; van der Pijl, Robbert J.; Bogaards, Sylvia J. P.; Conijn, Stefan; Peters, Eva L.; Begthel, Leon P. L.; Uijterwijk, Bas; Lindqvist, Johan; Langlais, Paul R.; Girbes, Armand R. J.; Stapel, Sandra; Granzier, Henk; Campbell, Kenneth S.; Ma, Weikang; Irving, Thomas; Hwee, Darren T.; Hartman, James J.; Malik, Fady I.; Paul, Marinus; Beishuizen, Albertus; Ochala, Julien; Heunks, Leo; Ottenheijm, Coen A. C.
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Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-05-27
err0
errOAAI
errHessel, Anthony L.; Kuehn, Michel N.; Han, Seong-Won; Ma, Weikang; Irving, Thomas C.; Momb, Brent A.; Song, Taejeong; Sadayappan, Sakthivel; Linke, Wolfgang A.; Palmer, Bradley M.
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errSave
Titin-Based Force Modulates Cardiac Thick and Thin Filaments
errCIRCULATION RESEARCH
IF16.2
err2024-04-12
err0
PREAI
errHessel, Anthony L.; Kuehn, Michel N.; Engels, Nichlas M.; Nissen, Devin L.; Freundt, Johanna K.; Ma, Weikang; Irving, Thomas C.; Linke, Wolfgang A.
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Myosin-binding protein C regulates the sarcomere lattice and stabilizes the OFF states of myosin heads
errNATURE COMMUNICATIONS
IF15.7
err2024-03-23
err3
errOAAI
errHessel, Anthony L.; Engels, Nichlas M.; Kuehn, Michel N.; Nissen, Devin; Sadler, Rachel L.; Ma, Weikang; Irving, Thomas C.; Linke, Wolfgang A.; Harris, Samantha P.
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Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-02-12
err2
PREAI
errMa, Weikang; del Rio, Carlos L.; Qi, Lin; Prodanovic, Momcilo; Mijailovich, Srboljub; Zambataro, Christopher; Gong, Henry; Shimkunas, Rafael; Gollapudi, Sampath; Nag, Suman; Irving, Thomas C.
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The structural OFF and ON states of myosin can be decoupled from the biochemical super- and disordered-relaxed states
errPNAS NEXUS
IF3.8
err2024-01-30
err10
errOAAI
errJani, Vivek P.; Song, Taejeong; Gao, Chengqian; Gong, Henry; Sadayappan, Sakthivel; Kass, David A.; Irving, Thomas C.; Ma, Weikang
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Cardiac Effects of EDG-7500, a Novel Cardiac Sarcomere Regulator: In vitro and in vivo Evidence for Slowing Isovolumic Contraction and Improved Ventricular Compliance
errCIRCULATION
IF38.6
err2023-11-07
err0
PREAI
errDel Rio, Carlos L.; Ma, Weikang; Irving, Thomas; Roof, Steve; Tolley, Jessica; Duvall, Mike; Hawryluk, Natalie; Russell, Alan; Semigran, Marc; Evanchik, Marc
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Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle
errCIRCULATION RESEARCH
IF16.2
err2023-08-18
err10
errOAAI
errKooiker, Kristina B.; Mohran, Saffie; Turner, Kyrah L.; Ma, Weikang; Martinson, Amy; Flint, Galina; Qi, Lin; Gao, Chengqian; Zheng, Yahan; Mcmillen, Timothy S.; Mandrycky, Christian; Mahoney-Schaefer, Max; Freeman, Jeremy C.; Arenas, Elijah Gabriela Costales; Tu, An-Yu; Irving, Thomas C.; Geeves, Michael A.; Tanner, Bertrand C. W.; Regnier, Michael; Davis, Jennifer; Moussavi-Harami, Farid
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Structural And Biochemical Effects Of Missense MyBP-C Mutations On The Myofilament In Human Hypertrophic Cardiomyopathy
errCIRCULATION RESEARCH
IF16.2
err2023-08-04
err0
PREAI
errMcAllister, Christopher M.; Jani, Vivek; Nissen, Devin L.; Ma, Weikang; Kass, David A.; Irving, Thomas C.; Day, Sharlene
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The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2023-07-03
err7
errOAAI
errMa, Weikang; Lee, Kyoung Hwan; Delligatti, Christine E.; Davis, M. Therese; Zheng, Yahan; Gong, Henry; Kirk, Jonathan A.; Craig, Roger; Irving, Thomas
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errSave
Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension
errCIRCULATION
IF38.6
err2023-06-20
err5
errOAAI
errJani, Vivek; Aslam, M. Imran; Fenwick, Axel J.; Ma, Weikang; Gong, Henry; Milburn, Gregory; Nissen, Devin; Salazar, Ilton M. Cubero M.; Hanselman, Olivia; Mukherjee, Monica; Halushka, Marc K.; Margulies, Kenneth B.; Campbell, Kenneth S.; Irving, Thomas C.; Kass, David A.; Hsu, Steven
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Research Directions

No research directions
Co-authors
Cooperation Journals
C
Christine E. Seidman
H-index: 151 · Papers: 708
A
Ad Bax
H-index: 145 · Papers: 626
D
David A. Kass
H-index: 137 · Papers: 790
J
J. Andrew McCammon
H-index: 134 · Papers: 1.1K
J
Jonathan G. Seidman
H-index: 132 · Papers: 534
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