Not logged in Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ Bubenik, Monica; Mader, Pavel; Orlicky, Stephen; Perryman, Alexander L.; Hamel, Martine; Godbout, Claude; Falgueyret, Jean-Pierre; Kurinov, Igor; Wong, Cassandra; Gingras, Anne Claude; Mamane, Yael; Zinda, Michael; Morris, Stephen J.; Gallant, Michel; Sfeir, Agnel; Black, W. Cameron; Durocher, Daniel; Zimmermann, Michal; Sicheri, Frank Share Save
SCFCdc4 Enables Mating Type Switching in Yeast by Cyclin-Dependent Kinase-Mediated Elimination of the Ash1 Transcriptional Repressor Liu, Qingquan; Larsen, Brett; Ricicova, Marketa; Orlicky, Stephen; Tekotte, Hille; Tang, Xiaojing; Craig, Karen; Quiring, Adam; Le Bihan, Thierry; Hansen, Carl; Sicheri, Frank; Tyers, Mike Share Save
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Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306 Szychowski, Janek; Papp, Robert; Dietrich, Evelyne; Liu, Bingcan; Vallee, Frederic; Leclaire, Marie-Eve; Fourtounis, Jimmy; Martino, Giovanni; Perryman, Alexander L.; Pau, Victor; Yin, Shou Yun; Mader, Pavel; Roulston, Anne; Truchon, Jean-Francois; Marshall, C. Gary; Diallo, Mohamed; Duffy, Nicole M.; Stocco, Rino; Godbout, Claude; Bonneau-Fortin, Alexanne; Kryczka, Rosie; Bhaskaran, Vivek; Mao, Daniel; Orlicky, Stephen; Beaulieu, Patrick; Turcotte, Pascal; Kurinov, Igor; Sicheri, Frank; Mamane, Yael; Gallant, Michel; Black, W. Cameron Share Save
Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex St-Cyr, Daniel; Ceccarelli, Derek F.; Orlicky, Stephen; van der Sloot, Almer M.; Tang, Xiaojing; Kelso, Susan; Moore, Susan; James, Clint; Posternak, Ganna; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Marinier, Anne; Sicheri, Frank; Tyers, Mike Share Save
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry Tavernier, N.; Thomas, Y.; Vigneron, S.; Maisonneuve, P.; Orlicky, S.; Mader, P.; Regmi, S. G.; Van Hove, L.; Levinson, N. M.; Gasmi-Seabrook, G.; Joly, N.; Poteau, M.; Velez-Aguilera, G.; Gavet, O.; Castro, A.; Dasso, M.; Lorca, T.; Sicheri, F.; Pintard, L. Share Save
A substrate binding model for the KEOPS tRNA modifying complex Beenstock, Jonah; Ona, Samara Mishelle; Porat, Jennifer; Orlicky, Stephen; Wan, Leo C. K.; Ceccarelli, Derek F.; Maisonneuve, Pierre; Szilard, Rachel K.; Yin, Zhe; Setiaputra, Dheva; Mao, Daniel Y. L.; Khan, Morgan; Raval, Shaunak; Schriemer, David C.; Bayfield, Mark A.; Durocher, Daniel; Sicheri, Frank Share Save
Functional characterization of a PROTAC directed against BRAF mutant V600E Posternak, Ganna; Tang, Xiaojing; Maisonneuve, Pierre; Jin, Ting; Lavoie, Hugo; Daou, Salima; Orlicky, Stephen; de Rugy, Theo Goullet; Caldwell, Lauren; Chan, Kin; Aman, Ahmed; Prakesch, Michael; Poda, Gennady; Mader, Pavel; Wong, Cassandra; Maier, Stefan; Kitaygorodsky, Julia; Larsen, Brett; Colwill, Karen; Yin, Zhe; Ceccarelli, Derek F.; Batey, Robert A.; Taipale, Mikko; Kurinov, Igor; Uehling, David; Wrana, Jeff; Durocher, Daniel; Gingras, Anne-Claude; Al-Awar, Rima; Therrien, Marc; Sicheri, Frank Share Save
An allosteric conduit facilitates dynamic multisite substrate recognition by the SCFCdc4 ubiquitin ligase Csizmok, Veronika; Orlicky, Stephen; Cheng, Jing; Song, Jianhui; Bah, Alaji; Delgoshaie, Neda; Lin, Hong; Mittag, Tanja; Sicheri, Frank; Chan, Hue Sun; Tyers, Mike; Forman-Kay, Julie D. Share Save
Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface Gorelik, Maryna; Orlicky, Stephen; Sartori, Maria A.; Tang, Xiaojing; Marcon, Edyta; Kurinov, Igor; Greenblatt, Jack F.; Tyers, Mike; Moffat, Jason; Sicheri, Frank; Sidhu, Sachdev S. Share Save
Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function Zeqiraj, Elton; Tian, Lei; Piggott, Christopher A.; Pillon, Monica C.; Duffy, Nicole M.; Ceccarelli, Derek F.; Keszei, Alexander F. A.; Lorenzen, Kristina; Kurinov, Igor; Orlicky, Stephen; Gish, Gerald D.; Heck, Albert J. R.; Guarne, Alba; Greenberg, Roger A.; Sicheri, Frank Share Save
Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity Huang, Hao; Zeqiraj, Elton; Dong, Beihua; Jha, Babal Kant; Duffy, Nicole M.; Orlicky, Stephen; Thevakumaran, Neroshan; Talukdar, Manisha; Pillon, Monica C.; Ceccarelli, Derek F.; Wan, Leo C. K.; Juang, Yu-Chi; Mao, Daniel Y. L.; Gaughan, Christina; Brinton, Margo A.; Perelygin, Andrey A.; Kourinov, Igor; Guarne, Alba; Silverman, Robert H.; Sicheri, Frank Share Save
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin Huang, Hao; Ceccarelli, Derek F.; Orlicky, Stephen; St-Cyr, Daniel J.; Ziemba, Amy; Garg, Pankaj; Plamondon, Serge; Auer, Manfred; Sidhu, Sachdev; Marinier, Anne; Kleiger, Gary; Tyers, Mike; Sicheri, Frank Share Save
OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function (vol 45, pg 384, 2012) Juang, Yu-Chi; Landry, Marie-Claude; Sanches, Mario; Vittal, Vinayak; Leung, Charles; Ceccarelli, Derek F.; Mateo, Abigail-Rachele F.; Pruneda, Jonathan N.; Mao, Dan; Szilard, Rachel K.; Orlicky, Stephen; Munro, Meagan; Brzovic, Peter S.; Klevit, Rachel E.; Sicheri, Frank; Durocher, Daniel Share Save
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OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function Juang, Yu-Chi; Landry, Marie-Claude; Sanches, Mario; Vittal, Vinayak; Leung, Charles C. Y.; Ceccarelli, Derek F.; Mateo, Abigail-Rachele F.; Pruneda, Jonathan N.; Mao, Daniel Y. L.; Szilard, Rachel K.; Orlicky, Stephen; Munro, Meagan; Brzovic, Peter S.; Klevit, Rachel E.; Sicheri, Frank; Durocher, Daniel Share Save
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Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine Mao, Daniel Y. L.; Neculai, Dante; Downey, Michael; Orlicky, Stephen; Haffani, Yosr Z.; Ceccarelli, Derek F.; Ho, Jenny S. L.; Szilard, Rachel K.; Zhang, Wei; Ho, Cynthia S.; Wan, Leo; Fares, Christophe; Rumpel, Sigrun; Kurinov, Igor; Arrowsmith, Cheryl H.; Durocher, Daniel; Sicheri, Frank Share Save
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