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Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements Raimondi, Federica; Siow, Kah Mun; Wrona, Dominik; Fuster-Garcia, Carla; Pastukhov, Oleksandr; Schmitz, Michael; Bargsten, Katja; Kissling, Lucas; Swarts, Daan C.; Andrieux, Geoffroy; Cathomen, Toni; Modlich, Ute; Jinek, Martin; Siler, Ulrich; Reichenbach, Janine Share Save
Engineering a Novel Probiotic Toolkit in Escherichia coli Nissle 1917 for Sensing and Mitigating Gut Inflammatory Diseases Weibel, Nathalie; Curcio, Martina; Schreiber, Atilla; Arriaga, Gabriel; Mausy, Marine; Mehdy, Jana; Brullmann, Lea; Meyer, Andreas; Roth, Len; Flury, Tamara; Pecina, Valerie; Starlinger, Kim; Dernic, Jan; Jungfer, Kenny; Ackle, Fabian; Earp, Jennifer; Hausmann, Martin; Jinek, Martin; Rogler, Gerhard; Westmann, Caua Antunes Share Save
HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing Reginato, Giordano; Dello Stritto, Maria Rosaria; Wang, Yanbo; Hao, Jingzhou; Pavani, Raphael; Schmitz, Michael; Halder, Swagata; Morin, Vincent; Cannavo, Elda; Ceppi, Ilaria; Braunshier, Stefan; Acharya, Ananya; Ropars, Virginie; Charbonnier, Jean-Baptiste; Jinek, Martin; Nussenzweig, Andre; Ha, Taekjip; Cejka, Petr Share Save
RNA-guided RNA silencing by an Asgard archaeal Argonaute Bastiaanssen, Carolien; Ugarte, Pilar Bobadilla; Kim, Kijun; Finocchio, Giada; Feng, Yanlei; Anzelon, Todd A.; Kostlbacher, Stephan; Tamarit, Daniel; Ettema, Thijs J. G.; Jinek, Martin; Macrae, Ian J.; Joo, Chirlmin; Swarts, Daan C.; Wu, Fabai Share Save
Enhancing prime editor activity by directed protein evolution in yeast Weber, Yanik; Bock, Desiree; Ivascu, Anastasia; Mathis, Nicolas; Rothgangl, Tanja; Ioannidi, Eleonora I.; Blaudt, Alex C.; Tidecks, Lisa; Vadovics, Mate; Muramatsu, Hiromi; Reichmuth, Andreas; Marquart, Kim F.; Kissling, Lucas; Pardi, Norbert; Jinek, Martin; Schwank, Gerald Share Save
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PAM-flexible genome editing with an engineered chimeric Cas9 Zhao, Lin; Koseki, Sabrina R. T.; Silverstein, Rachel A.; Amrani, Nadia; Peng, Christina; Kramme, Christian; Savic, Natasha; Pacesa, Martin; Rodriguez, Tomas C.; Stan, Teodora; Tysinger, Emma; Hong, Lauren; Yudistyra, Vivian; Ponnapati, Manvitha R.; Jacobson, Joseph M.; Church, George M.; Jakimo, Noah; Truant, Ray; Jinek, Martin; Kleinstiver, Benjamin P.; Sontheimer, Erik J.; Chatterjee, Pranam Share Save
Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility Schmidheini, Lukas; Mathis, Nicolas; Marquart, Kim Fabiano; Rothgangl, Tanja; Kissling, Lucas; Bock, Desiree; Chanez, Christelle; Wang, Jingrui Priscilla; Jinek, Martin; Schwank, Gerald Share Save
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Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells Donohoue, Paul D.; Pacesa, Martin; Lau, Elaine; Vidal, Bastien; Irby, Matthew J.; Nyer, David B.; Rotstein, Tomer; Banh, Lynda; Toh, Mckenzi S.; Gibson, Jason; Kohrs, Bryan; Baek, Kevin; Owen, Arthur L. G.; Slorach, Euan M.; van Overbeek, Megan; Fuller, Christopher K.; May, Andrew P.; Jinek, Martin; Cameron, Peter Share Save
Hakai is required for stabilization of core components of the m6A mRNA methylation machinery Bawankar, Praveen; Lence, Tina; Paolantoni, Chiara; Haussmann, Irmgard U.; Kazlauskiene, Migle; Jacob, Dominik; Heidelberger, Jan B.; Richter, Florian M.; Nallasivan, Mohanakarthik P.; Morin, Violeta; Kreim, Nastasja; Beli, Petra; Helm, Mark; Jinek, Martin; Soller, Matthias; Roignant, Jean-Yves Share Save
The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response Asanovi, Igor; Strandback, Emilia; Kroupova, Alena; Pasajlic, Djurdja; Meinhart, Anton; Tsung-Pin, Pai; Djokovic, Nemanja; Anrather, Dorothea; Schuetz, Thomas; Suskiewicz, Marcin Jozef; Sillamaa, Sirelin; Kocher, Thomas; Beveridge, Rebecca; Nikolic, Katarina; Schleiffer, Alexander; Jinek, Martin; Hartl, Markus; Clausen, Tim; Penninger, Josef; Macheroux, Peter; Weitzer, Stefan; Martinez, Javier Share Save
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels Rothgangl, Tanja; Dennis, Melissa K.; Lin, Paulo J. C.; Oka, Rurika; Witzigmann, Dominik; Villiger, Lukas; Qi, Weihong; Hruzova, Martina; Kissling, Lucas; Lenggenhager, Daniela; Borrelli, Costanza; Egli, Sabina; Frey, Nina; Bakker, Noelle; Walker, John A., II; Kadina, Anastasia P.; Victorov, Denis V.; Pacesa, Martin; Kreutzer, Susanne; Kontarakis, Zacharias; Moor, Andreas; Jinek, Martin; Weissman, Drew; Stoffel, Markus; van Boxtel, Ruben; Holden, Kevin; Pardi, Norbert; Thoeny, Beat; Haeberle, Johannes; Tam, Ying K.; Semple, Sean C.; Schwank, Gerald Share Save
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