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Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers Ito, Takahiro; Young, Michael J.; Li, Ruitong; Jain, Sidharth; Wernitznig, Andreas; Krill-Burger, John M.; Lemke, Christopher T.; Monducci, Davide; Rodriguez, Diego J.; Chang, Liang; Dutta, Sanjukta; Pal, Debjani; Paolella, Brenton R.; Rothberg, Michael V.; Root, David E.; Johannessen, Cory M.; Parida, Laxmi; Getz, Gad; Vazquez, Francisca; Doench, John G.; Zamanighomi, Mahdi; Sellers, William R. Share Save
Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist Garcia-Martinez, Juan Manuel; Wang, Shirley; Weishaeupl, Cordula; Wernitznig, Andreas; Chetta, Paolo; Pinto, Catarina; Ho, Jason; Dutcher, Darrin; Gorman, Philip N.; Kroe-Barrett, Rachel; Rinnenthal, Joerg; Giragossian, Craig; Impagnatiello, Maria Antonietta; Tirapu, Inigo; Hilberg, Frank; Kraut, Norbert; Pearson, Mark; Kuenkele, Klaus Peter Share Save
CLIFF, a bioinformatics software tool to explore molecular differences between two sets of cancer cell lines Wernitznig, Andreas; Lipp, Jesse J.; Zichner, Thomas; Gerlach, Daniel; Bauer, Markus J.; Voss, Tilman; Schlattl, Andreas; Haslinger, Christian; Montgomery, Philip G.; Zamanighomi, Mahdi; Sellers, William R.; Kraut, Norbert Share Save
Targeting IAP in cancer: BI 891065 a potent small molecule SMAC mimetic that synergizes with immune checkpoint inhibition Aichinger, Martin; Santoro, Valeria; Slavic-Obradovic, Ksenija; Ruhland, Stefanie; Wernitznig, Andreas; Neudolt, Andrea; Schaefer, Markus; Kallenda, Sabine; Zach, Daniel; Olt, Sabine; Salomon, Carina; Rieser, Sarah; Weissenboeck, Martina; Ebner, Florian; Schlattl, Andreas; De Almeida, Melanie Talata; Langlois, Rebecca; Sykora, Martina; Reschke, Markus; Zichner, Thomas; Gerlach, Daniel; Jude, Julian; Fellner, Michaela; Scharn, Dirk; Kraut, Norbert; Moll, Juergen; Zuber, Johannes; Carotta, Sebastian; Impagnatiello, Maria Antonietta; Tontsch-Grunt, Ulrike Share Save
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells Lieb, Simone; Blaha-Ostermann, Silvia; Kamper, Elisabeth; Ehrenhoefer-Woelfer, Katharina; Schlattl, Andreas; Wernitznig, Andreas; Lipp, Jesse; Nagasaka, Kota; Bader, Gerd; Neumueller, Ralph; Kraut, Norbert; Pearson, Mark; Woehrle, Simon; Petronczki, Mark Share Save
BI 905711, a novel CDH17-targeting TRAILR2 agonist, effectively triggers tumor cell apoptosis and tumor regressions selectively in CDH17-positive colorectal cancer models Garcia-Martinez, Juan Manuel; Wernitznig, Andreas; Rinnenthal, Joerg; Impagnatiello, Maria Antonietta; Hilberg, Frank; Giragossian, Craig; Kraut, Norbert; Pearson, Mark; Kuenkele, Klaus-Peter Share Save
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells Lieb, Simone; Blaha-Ostermann, Silvia; Kamper, Elisabeth; Rippka, Janine; Schwarz, Cornelia; Ehrenhoefer-Woelfer, Katharina; Schlattl, Andreas; Wernitznig, Andreas; Lipp, Jesse J.; Nagasaka, Kota; van der Lelij, Petra; Bader, Gerd; Koi, Minoru; Goel, Ajay; Neumueller, Ralph A.; Peters, Jan-Michael; Kraut, Norbert; Pearson, Mark A.; Petronczki, Mark; Woehrle, Simon Share Save
A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer Zoranovic, Tamara; Manent, Jan; Willoughby, Lee; de Simoes, Ricardo Matos; La Marca, John E.; Golenkina, Sofya; Xia Cuiping; Gruber, Susanne; Angjeli, Belinda; Kanitz, Elisabeth Eva; Cronin, Shane J. F.; Neely, G. Gregory; Wernitznig, Andreas; Humbert, Patrick O.; Simpson, Kaylene J.; Mitsiades, Constantine S.; Richardson, Helena E.; Penninger, Josef M. Share Save
BI 907828: A novel, potent MDM2 inhibitor that induces antitumor immunologic memory and acts synergistically with an anti-PD-1 antibody in syngeneic mouse models of cancer Rudolph, Dorothea; Reschke, Markus; Blake, Sophia; Rinnenthal, Joerg; Wernitznig, Andreas; Weyer-Czernilofsky, Ulrike; Gollner, Andreas; Haslinger, Christian; Garin-Chesa, Pilar; Quant, Jens; McConnell, Darryl B.; Norbert, Kraut; Moll, Juergen Share Save
A novel, potent MDM2 inhibitor that is suitable for high-dose intermittent schedules Rudolph, Dorothea; Gollner, Andreas; Blake, Sophia; Rinnenthal, Joerg; Wernitznig, Andreas; Weyer-Czernilofsky, Ulrike; Haslinger, Christian; Garin-Chesa, Pilar; Quant, Jens; McConnell, Darryl B.; Moll, Juergen; Norbert, Kraut Share Save
BI 907828: A highly potent MDM2 inhibitor with low human dose estimation, designed for high-dose intermittent schedules in the clinic Rinnenthal, Joerg; Rudolph, Dorothea; Blake, Sophia; Gollner, Andreas; Wernitznig, Andreas; Weyer-Czernilofsky, Ulrike; Haslinger, Christian; Garin-Chesa, Pilar; Moll, Juergen; Kraut, Norbert; McConnell, Darryl; Quant, Jens Share Save
The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy Sanderson, Michael P.; Hofmann, Marco H.; Garin-Chesa, Pilar; Schweifer, Norbert; Wernitznig, Andreas; Fischer, Stefan; Jeschko, Astrid; Meyer, Reiner; Moll, Juergen; Pecina, Thomas; Arnhof, Heribert; Weyer-Czernilofsky, Ulrike; Zahn, Stephan K.; Adolf, Unther R.; Kraut, Norbert Share Save
BI5: a novel SMAC mimetic that triggers tumor cell death and potentiates PD-1 mediated cancer therapy Reschke, Markus; Impagnatiello, Maria Antonietta; Reiser, Ulrich; Scharn, Dirk; Spevak, Walter; Savchenko, Alexander; Wernitznig, Andreas; Sykora, Martina; Langlois, Rebecca; Zier, Elisabeth; Zach, Daniel; Kallenda, Sabine; Garin-Chesa, Pilar; Quant, Jens; Pearson, Mark; McConnell, Darryl; Kraut, Norbert; Moll, Juergen Share Save
Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms Unger, C.; Kramer, N.; Unterleuthner, D.; Scherzer, M.; Burian, A.; Rudisch, A.; Stadler, M.; Schlederer, M.; Lenhardt, D.; Riedl, A.; Walter, S.; Wernitznig, A.; Kenner, L.; Hengstschlger, M.; Schler, J.; Sommergruber, W.; Dolznig, H. Share Save
Efficacy and Mechanism of Action of Volasertib, a Potent and Selective Inhibitor of Polo-Like Kinases, in Preclinical Models of Acute Myeloid Leukemia Rudolph, Dorothea; Impagnatiello, Maria Antonietta; Blaukopf, Claudia; Sommer, Christoph; Gerlich, Daniel W.; Roth, Mareike; Tontsch-Grunt, Ulrike; Wernitznig, Andreas; Savarese, Fabio; Hofmann, Marco H.; Albrecht, Christoph; Geiselmann, Lena; Reschke, Markus; Garin-Chesa, Pilar; Zuber, Johannes; Moll, Juergen; Adolf, Guenther R.; Kraut, Norbert Share Save
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The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity Aigner, K.; Dampier, B.; Descovich, L.; Mikula, M.; Sultan, A.; Schreiber, M.; Mikulits, W.; Brabletz, T.; Strand, D.; Obrist, P.; Sommergruber, W.; Schweifer, N.; Wernitznig, A.; Beug, H.; Foisner, R.; Eger, A. Share Save
The transcription factor ZEB1 (δEF1) represses Plakophilin 3 during human cancer progression Aigner, Kirsten; Descovich, Luise; Mikula, Mario; Sultan, Aneesa; Dampier, Brigitta; Bonne, Stefan; van Roy, Frans; Mikulits, Wolfgang; Schreiber, Martin; Brabletz, Thomas; Sommergruber, Wolfgang; Schweifer, Norbert; Wernitznig, Andreas; Beug, Hartmut; Foisner, Roland; Eger, Andreas Share Save
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