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William R. Sellers

MIT and Harvard

118H-index
816Paper Count
8.5WCitation Count
Published Papers 175
Publication Date
Context-dependent synthetic lethality — an emerging precision therapeutic approach
err2026-04-23
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PREAI
errLiang Chang; Katharin Shaw; Francisca Vazquez; William R. Sellers
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Mechanisms of Clinical Resistance to Selective FGFR2 Inhibition by Lirafugratinib
err2026-01-20
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PREAI
errH. Ellis; E.R. Balasooriya; A. Varkaris; B. Hajian; J. Wan; M. Shekhar; I. Gritti; V. Vijay; L. Albertelli; S. Piot; K. Lau; A. Kehlmann; N. Chevalier; F.W. Nugent; Y. Zhen; V.S. Silveira; W.R. Sellers; R.B. Corcoran; D. Juric; N. Bardeesy
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Prospects for understanding and exploiting the consequences of hyperactivation lethality
err2025-05-19
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errOAAI
errKatharin Shaw; René Bernards; Kimberly Stegmaier; Harold Varmus; William R. Sellers
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Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5
err2025-02-01
err0
PREAI
errJin, Cyrus Y.; Hunkeler, Moritz; Mulvaney, Kathleen M.; Sellers, William R.; Fischer, Eric S.
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A Kinetic Scout Approach Accelerates Targeted Protein Degrader Development
err2024-12-16
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errOAAI
errFan, Angela T.; Gadbois, Gillian E.; Huang, Hai-Tsang; Chaudhry, Charu; Jiang, Jiewei; Sigua, Logan H.; Smith, Emily R.; Wu, Sitong; Poirier, Grace J.; Dunne-Dombrink, Kara; Goyal, Pavitra; Tao, Andrew J.; Sellers, William R.; Fischer, Eric S.; Donovan, Katherine A.; Ferguson, Fleur M.
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Editor's Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells
err2024-08-01
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errOAAI
errBerger, Raanan; Febbo, Phillip G.; Majumder, Pradip K.; Zhao, Jean J.; Mukherjee, Shayan; Signoretti, Sabina; Campbell, K. Thirza; Sellers, William R.; Roberts, Thomas M.; Loda, Massimo; Golub, Todd R.; Hahn, William C.
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A ubiquitin-specific proximity labeling method to study drug-induced ubiquitylation
err2024-03-22
err0
PREAI
errHuang, Hai-Tsang; Lumpkin, Ryan J.; Tsai, Ryan W.; Donovan, Katherine A.; Su, Shuyao; Zhao, Xu; Chen, James; Fischer, Eric S.; Sellers, William R.
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Creating a living public oncology drug resource using PRISM cell line viability screening
err2024-03-22
err0
PREAI
errRees, Matthew G.; Kocak, Mustafa; Mapa, Claudine; Frederick, Dennie; Nguyen, Ellen; Kalathungal, Alvin; Fazio, Anthony; Davis, John F.; Reeves, Emily; Tucci, Ariah; Barry, Rachael; Harrington, Colleen; Eskra, Jillian; Ronan, Melissa M.; Sellers, William R.; Roth, Jennifer A.
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Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates
err2024-03-21
err5
PREAI
errHuang, Hai-Tsang; Lumpkin, Ryan J.; Tsai, Ryan W.; Su, Shuyao; Zhao, Xu; Xiong, Yuan; Chen, James; Mageed, Nada; Donovan, Katherine A.; Fischer, Eric S.; Sellers, William R.
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Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities (vol 55, pg 1709, 2023)
err2024-02-23
err0
errOAAI
errChang, Liang; Jung, Nancy Y.; Atari, Adel; Rodriguez, Diego J.; Kesar, Devishi; Song, Tian-Yu; Rees, Matthew G.; Ronan, Melissa; Li, Ruitong; Ruiz, Paloma; Chaturantabut, Saireudee; Ito, Takahiro; van Tienen, Laurens M.; Tseng, Yuen-Yi; Roth, Jennifer A.; Sellers, William R.
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Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities
err2023-09-25
err13
PREAI
errChang, Liang; Jung, Nancy Y.; Atari, Adel; Rodriguez, Diego J.; Kesar, Devishi; Song, Tian-Yu; Rees, Matthew G.; Ronan, Melissa; Li, Ruitong; Ruiz, Paloma; Chaturantabut, Saireudee; Ito, Takahiro; van Tienen, Laurens M.; Tseng, Yuen-Yi; Roth, Jennifer A.; Sellers, William R.
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Downregulation of the HIF2a target cyclin D1 underlies the efficacy of the HIF2a inhibitor belzutifan in kidney cancer.
err2023-08-15
err0
PREAI
errShirole, Nitin H.; Kesar, Devishi; Sellers, William R.; Kaelin, William G., Jr.
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Hit-finding by Cysteine-Scanning (HCS): A method for finding druggable pockets
err2023-05-01
err0
PREAI
errvan Tienen, Laurens Moore; Bayoumi, Shadwa; Muneeruddin, Khaja; Leymarie, Nancy; Kornfilt, David; Bian, Yuemin; Kesar, Devishi; Li, Ruitong; Atack, Thomas; Popa, Alexandra-Mariela; Jandova, Zuzana; Trollmann, Philipp; Bergner, Andreas; Rumpel, Klaus; Kessler, Dirk; Sellers, William R.
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Systematic profiling of conditional pathway activation as a new class of cancer dependency
err2023-04-04
err0
PREAI
errChang, Liang; Jung, Nancy Y.; Atari, Adel; Kesar, Devishi; Rodriguez, Diego J.; Rees, Matthew A.; Ronan, Melissa; Sellers, William R.
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Novel FGFR2 biparatopic antibodies for the treatment of cholangiocarcinoma
err2023-04-04
err0
PREAI
errChaturantabut, Saireudee; Oliver, Sydney; Kim, John; Frederick, Dennie; Robinson, Foxy; Sinopoli, Alessandro; Rodriguez, Diego J.; Chang, Liang; Bardeesy, Nabeel; Sellers, William
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Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors
err2023-04-01
err7
errOAAI
errTiedt, Ralph; King, Frederick J.; Stamm, Christelle; Niederst, Matthew J.; Delach, Scott; Zumstein-Mecker, Sabine; Meltzer, Jodi; Mulford, Iain J.; Labrot, Emma; Engstler, Barbara Schacher; Baltschukat, Sabrina; Kerr, Grainne; Golji, Javad; Wyss, Daniel; Schnell, Christian; Ainscow, Edward; Engelman, Jeffrey A.; Sellers, William R.; Barretina, Jordi; Caponigro, Giordano; Porta, Diana Graus
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Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle
err2023-03-28
err112
errOAAI
errMiyake, S; Sellers, WR; Safran, M; Li, XT; Zhao, WQ; Grossman, SR; Gan, JM; DeCaprio, JA; Adams, PD; Kaelin, WG
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Phosphorylation of the PTEN tail regulates protein stability and function
err2023-03-28
err769
errOAAI
errVazquez, F; Ramaswamy, S; Nakamura, N; Sellers, WR
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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
err2023-03-28
err540
errOAAI
errNakamura, N; Ramaswamy, S; Vazquez, F; Signoretti, S; Loda, M; Sellers, WR
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