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Christian Heinis

ecole polytechnique federale de lausanne

40H-index
166Paper Count
7.2KCitation Count
Published Papers 61
Publication Date
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Peptide ligand discovery of G protein-coupled receptors
errNature Reviews Methods Primers
IF56
err2026-07-16
err0
PREAI
errJulius Hermes; Marin Matic; Ho Yan Yeung; Qianru Jiang; Lauri Urvas; Elizaveta Korchevaya; Tomasz Stepniewski; Alexandre Murza; Jana Selent; Michael Freissmuth; Christian Heinis; Pierre-Luc Boudreault; Jens Carlsson; Tao Che; Helena Safavi-Hemami; Alexander S. Hauser; Christian W. Gruber
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Generation of membrane-permeable cyclic peptides inhibiting protein–protein interaction
errNature Chemical Biology
IF13.7
err2026-06-01
err0
PREAI
errXinjian Ji; Lluc Farrera-Soler; Jiajun Li; Gontran Sangouard; Nathan De Sadeleer; Alexander L. Nielsen; Ganesh K. Mothukuri; Anne Zarda; Edward J. Will; Florence Pojer; Kelvin Lau; Christian Heinis
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Yeast Display Technology Enables Rapid Discovery of Low-Nanomolar Macrocyclic Peptide Inhibitors of Human Angiotensin-Converting Enzyme 2
errJournal of Medicinal Chemistry
IF6.8
err2026-03-24
err0
errOAAI
errZhanna Romanyuk; Giacomo Bettin; Paul Brear; Sara Linciano; Ylenia Mazzocato; Simone Bonadies; Ilaria Zanotto; Camilla Mazzucco; Alan Monferone; Miguel A. Soler; Gianfranco Pasut; Sara De Martin; Alessandro Scarso; Christian Heinis; Sylvia Rothenberger; Marko Hyvönen; Alessandro Angelini
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Ligand-Directed Site-Selective Cysteine Bioconjugation of the KELCH Domain of KEAP1 with Hypervalent Iodine Reagents
errJournal of the American Chemical Society
IF15.6
err2025-11-04
err0
errOAAI
errChristine Marty; Xinjian Ji; Stefano Nicolai; Christian Heinis; Jerome Waser
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Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-05-24
err3
errOAAI
errNielsen, Alexander L.; Bognar, Zsolt; Mothukuri, Ganesh K.; Zarda, Anne; Schuttel, Mischa; Merz, Manuel L.; Ji, Xinjian; Will, Edward J.; Chinellato, Monica; Bartling, Christian R. O.; Stromgaard, Kristian; Cendron, Laura; Angelini, Alessandro; Heinis, Christian
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De novo development of small cyclic peptides that are orally bioavailable
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-12-28
err19
errOAAI
errMerz, Manuel L.; Habeshian, Sevan; Li, Bo; David, Jean-Alexandre G. L.; Nielsen, Alexander L.; Ji, Xinjian; Il Khwildy, Khaled; Benitez, Maury M. Duany; Phothirath, Phoukham; Heinis, Christian
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Cyclic Peptides for Drug Development
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2023-10-23
err71
errOAAI
errJi, Xinjian; Nielsen, Alexander L.; Heinis, Christian
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errSave
Peptide-Hypervalent Iodine Reagent Chimeras: Enabling Peptide Functionalization and Macrocyclization
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2023-07-07
err8
errOAAI
errLiu, Xing-Yu; Ji, Xinjian; Heinis, Christian; Waser, Jerome
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errSave
High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays
errNATURE COMMUNICATIONS
IF15.7
err2023-05-17
err6
errOAAI
errDiaz-Perlas, Cristina; Ricken, Benjamin; Farrera-Soler, Lluc; Guschin, Dmitrii; Pojer, Florence; Lau, Kelvin; Gerhold, Christian-Benedikt; Heinis, Christian
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errSave
Motifs for making tricycles
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-05-08
err0
errOAAI
errHeinis, Christian
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errSave
Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale
errNATURE COMMUNICATIONS
IF15.7
err2022-07-02
err22
errOAAI
errHabeshian, Sevan; Merz, Manuel Leonardo; Sangouard, Gontran; Mothukuri, Ganesh Kumar; Schuettel, Mischa; Bognar, Zsolt; Diaz-Perlas, Cristina; Vesin, Jonathan; Chapalay, Julien Bortoli; Turcatti, Gerardo; Cendron, Laura; Angelini, Alessandro; Heinis, Christian
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errSave
Phage Display Selected Cyclic Peptide Inhibitors of Kallikrein-Related Peptidases 5 and 7 and Their In Vivo Delivery to the Skin
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-06-02
err4
errOAAI
errGonschorek, Patrick; Zorzi, Alessandro; Maric, Tamara; Le Jeune, Mathilde; Schuettel, Mischa; Montagnon, Mathilde; Gomez-Ojea, Rebeca; Vollmar, Denis Patrick; Whitfield, Chantal; Reymond, Luc; Carle, Vanessa; Verma, Hitesh; Schilling, Oliver; Hovnanian, Alain; Heinis, Christian
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Cyclative Release Strategy to Obtain Pure Cyclic Peptides Directly from the Solid Phase
errACS CHEMICAL BIOLOGY
IF3.8
err2022-01-11
err7
errOAAI
errHabeshian, Sevan; Sable, Ganesh A.; Schuettel, Mischa; Merz, Manuel L.; Heinis, Christian
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errSave
Picomole-Scale Synthesis and Screening of Macrocyclic Compound Libraries by Acoustic Liquid Transfer
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2021-08-25
err18
errOAAI
errSangouard, Gontran; Zorzi, Alessandro; Wu, Yuteng; Ehret, Edouard; Schuettel, Mischa; Kale, Sangram; Diaz-Perlas, Cristina; Vesin, Jonathan; Bortoli Chapalay, Julien; Turcatti, Gerardo; Heinis, Christian
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Development of Selective FXIa Inhibitors Based on Cyclic Peptides and Their Application for Safe Anticoagulation
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-05-11
err7
errOAAI
errCarle, Vanessa; Wu, Yuteng; Mukherjee, Rakesh; Kong, Xu-Dong; Rogg, Chloe; Laurent, Quentin; Cecere, Enza; Villequey, Camille; Konakalla, Madhuree S.; Maric, Tamara; Lamers, Christina; Diaz-Perlas, Cristina; Butler, Kaycie; Goto, Junko; Stegmayr, Bernd; Heinis, Christian
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Combination of polycarboxybetaine coating and factor XII inhibitor reduces clot formation while preserving normal tissue coagulation during extracorporeal life support
errBIOMATERIALS
IF12.9
err2021-05-01
err36
errOAAI
errNaito, Noritsugu; Ukita, Rei; Wilbs, Jonas; Wu, Kan; Lin, Xiaojie; Carleton, Neil M.; Roberts, Kalliope; Jiang, Shaoyi; Heinis, Christian; Cook, Keith E.
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In Vitro-Evolved Peptides Bind Monomeric Actin and Mimic Actin-Binding Protein Thymosin-β4
errACS CHEMICAL BIOLOGY
IF3.8
err2021-04-12
err2
errOAAI
errGuebeli, Raphael J.; Bertoldo, Davide; Shimada, Kenji; Gerhold, Christian B.; Hurst, Verena; Takahashi, Yuichiro; Harada, Kai; Mothukuri, Ganesh K.; Wilbs, Jonas; Harata, Masahiko; Gasser, Susan M.; Heinis, Christian
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Cys-Cys and Cys-Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2021-03-08
err50
errOAAI
errCeballos, Javier; Grinhagena, Elija; Sangouard, Gontran; Heinis, Christian; Waser, Jerome
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errSave
Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product
errACS CHEMICAL BIOLOGY
IF3.8
err2020-10-30
err17
errOAAI
errKong, Xu-Dong; Carle, Vanessa; Diaz-Perlas, Cristina; Butler, Kaycie; Heinis, Christian
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errSave
Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy
errTHROMBOSIS AND HAEMOSTASIS
IF4.3
err2020-09-13
err7
PREAI
errBertaggia Calderara, Debora; Zermatten, Maxime G.; Aliotta, Alessandro; Batista Mesquita Sauvage, Ana P.; Carle, Vanessa; Heinis, Christian; Alberio, Lorenzo
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Research Directions

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Co-authors
Cooperation Journals
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Susan M. Gasser
H-index: 97 · Papers: 380
S
Shaoyi Jiang
H-index: 96 · Papers: 294
F
Freddy Radtke
H-index: 93 · Papers: 256
G
Greg Winter
H-index: 87 · Papers: 230
R
Rosario Scopelliti
H-index: 87 · Papers: 2.0K
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