Not logged inThe Discovery of MORF-627, a Highly Selective Conformationally-Biased Zwitterionic Integrin αvβ6 Inhibitor for Fibrosis
Harrison, Bryce A.; Dowling, James E.; Bursavich, Matthew G.; Troast, Dawn M.; Chong, Katherine M.; Hahn, Kristopher N.; Zhong, Cheng; Mulvihill, Kristen M.; Nguyen, Hanh; Monroy, Meghan F.; Qiao, Qi; Sosa, Brian; Mostafavi, Siavash; Smukste, Inese; Lee, Dooyoung; Cappellucci, Laura; Konopka, Elizabeth H.; Nowakowski, Patrycja; Stawski, Lukasz; Senices, Mayra; Nguyen, Minh Hai; Kapoor, Parmita S.; Luus, Lia; Sullivan, Andrew; Bortolato, Andrea; Svensson, Mats; Hickey, Eugene R.; Konze, Kyle D.; Day, Tyler; Kim, Byungchan; Negri, Ana; Gerasyuto, Aleksey I.; Moy, Terence I.; Lu, Min; Ray, Adrian S.; Wang, Liangsu; Cui, Dan; Lin, Fu-Yang; Lippa, Blaise; Rogers, Bruce N. .png)
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SaveTumor-targeted activation of CD137 using Bicycles: New insights into mechanism of action and discovery of BT7455, a clinical candidate for the treatment of EphA2-expressing cancersLahdenranta, Johanna; Hurov, Kristen; Cohen, Heather; Luus, Lia; Bray, Cara; Brown, Peter; Devlen, Anna; Campbell, Carly; Gray, Matthew; Kelly, Mike; Mudd, Gemma; Upadhyaya, Punit; Battula, Sailaja; Zhang, Kelvin; Dugast, Anne-Sophie; McDonnell, Kevin; Brandish, Phil; Keen, Nicholas Share Save EphA2-dependent CD137 agonism and anti-tumor efficacy by BT7455, a Bicycle tumor-targeted immune cell agonist®Luus, Lia; Hurov, Kristen; Lahdenranta, Johanna; Shah, Chinmayee; Devlen, Anna; Kristensson, Julia; Brown, Peter; Bray, Cara; Cohen, Heather; Campbell, Carly; Mudd, Gemma; Upadhyaya, Punit; McDonnell, Kevin; Xu, Hongmei; Jeffrey, Phil; Brandish, Philip E.; Keen, Nicholas Share Save Selective inhibition of integrin αvβ6 leads to rapid induction of urinary bladder tumors in cynomolgus macaquesGuffroy, Magali; Trela, Bruce; Kambara, Takahito; Stawski, Lukasz; Chen, Huidong; Luus, Lia; Montesinos, Monica S.; Olson, Lauren; He, Yupeng; Maisonave, Kevin; Carr, Tracy; Lu, Min; Ray, Adrian S.; Hazelwood, Lisa A. Share Save BT7455, A FULLY SYNTHETIC BICYCLE TUMORTARGETED IMMUNE CELL AGONIST®, LEADS TO POTENT EPHA2-DEPENDENT CD137 AGONISM AND ROBUST ANTI-TUMOR EFFICACYHurov, Kristen; Luus, Lia; Lahdenranta, Johanna; Upadhyaya, Punit; Cohen, Heather; Shah, Chinmayee; Kristensson, Julia; Brown, Peter; Mudd, Gemma; Campbell, Carly; Repash, Elizabeth; Haines, Eric; Battula, Sailaja; Kelly, Mike; Jeffrey, Phil; Beswick, Paul; Chen, Liuhong; McDonnell, Kevin; Brandish, Philip; Keen, Nicholas Share Save Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncologyUpadhyaya, Punit; Kristensson, Julia; Lahdenranta, Johanna; Repash, Elizabeth; Ma, Jun; Kublin, Jessica; Mudd, Gemma E.; Luus, Lia; Jeffrey, Phil; Hurov, Kristen; McDonnell, Kevin; Keen, Nicholas Share Save Share Save Targeting EphA2 in Bladder Cancer Using a Novel Antibody-Directed NanotherapeuticKamoun, Walid; Swindell, Elden; Pien, Christine; Luus, Lia; Cain, Jason; Pham, Minh; Kandela, Irawati; Huang, Zhaohua Richard; Tipparaju, Suresh K.; Koshkaryev, Alexander; Askoxylakis, Vasileios; Kirpotin, Dmitri B.; Bloom, Troy; Mino-Kenudson, Mari; Marks, James D.; Zalutskaya, Alena; Bshara, Wiam; Morrison, Carl; Drummond, Daryl C. Share Save Synergy between EphA2-ILs-DTXp, a Novel EphA2-Targeted Nanoliposomal Taxane, and PD-1 Inhibitors in Preclinical Tumor ModelsKamoun, Walid S.; Dugast, Anne-Sophie; Suchy, James J.; Grabow, Stephanie; Fulton, Ross B.; Sampson, James F.; Luus, Lia; Santiago, Michael; Koshkaryev, Alexander; Sun, Gang; Askoxylakis, Vasileios; Tam, Eric; Huang, Zhaohua Richard; Drummond, Daryl C.; Sawyer, Andrew J. Share Save Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunityTam, Eric M.; Fulton, Ross B.; Sampson, James F.; Muda, Marco; Camblin, Adam; Richards, Jennifer; Koshkaryev, Alexander; Tang, Jian; Kurella, Vinodh; Jiao, Yang; Xu, Lihui; Zhang, Kathy; Kohli, Neeraj; Luus, Lia; Hutto, Elizabeth; Kumar, Sandeep; Lulo, James; Paragas, Violette; Wong, Christina; Suchy, James; Grabow, Stephanie; Dugast, Anne-Sophie; Zhang, Hong; Depis, Fabien; Feau, Sonia; Jakubowski, Aniela; Qiao, Wenlian; Craig, Galina; Razlog, Maja; Qiu, James; Zhou, Yu; Marks, James D.; Croft, Michael; Drummond, Daryl C.; Raue, Andreas Share Save Mechanism of action of a novel agonist TNFR2 antibody that induces co-stimulation of T cells and promotes robust anti-tumor immunityFulton, Ross B.; Camblin, Adam; Sampson, James F.; Richards, Jennifer; Wong, Christina; Koshkaryev, Alexander; Luus, Lia; Jiao, Yang; Xu, Lihui; Paragas, Violette; Razlog, Maja; Muda, Marco; Tam, Eric M.; Drummond, Daryl C.; Raue, Andreas Share Save Development of a second-generation TRAIL agonist and predictive biomarker profile for colorectal cancerGhassemifar, Sara; Hashambhoy-Ramsay, Yasmin; Yuzugullu, Haluk; Utermark, Tamara; Paragas, Violette; Maiwald, Tim; Luus, Lia; Razlog, Maja; Hudson, Hann Ah; Chai, Diane; Schoeberl, Birgit; Reynolds, C. Patrick; Sorger, Peter; Sawyer, Andrew J.; Drummond, Daryl C.; Tam, Eric Share Save MM-401, a novel anti-TNFR2 antibody that induces T cell co-stimulation, robust anti-tumor activity and immune memoryRichards, Jennifer; Wong, Christina; Koshkaryev, Alexander; Fulton, Ross; Camblin, Adam; Sampson, James; Luus, Lia; Suchy, James; Grabow, Stephanie; Kurella, Vinodh; Kumar, Sandeep; Lulo, James; Qiu, James; Jiao, Yang; Xu, Lihui; Paragas, Violette; Razlog, Maja; Muda, Marco; Tam, Eric; Raue, Andreas; Drummond, Daryl Share Save Share Save Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse modelsKamoun, Walid S.; Kirpotin, Dmitri B.; Huang, Zhaohua Richard; Tipparaju, Suresh K.; Noble, Charles O.; Hayes, Mark E.; Luus, Lia; Koshkaryev, Alexander; Kim, Jaeyeon; Olivier, Ken; Kornaga, Tad; Oyama, Shinji; Askoxylakis, Vasileios; Pien, Christine; Kuesters, Geoffrey; Dumont, Nancy; Lugovskoy, Alexey A.; Schihl, Sarah A.; Wilton, John H.; Geddie, Melissa L.; Suchy, James; Grabow, Stephanie; Kohli, Neeraj; Reynolds, C. Patrick; Blaydes, Rachel; Zhou, Yu; Sawyer, Andrew J.; Marks, James D.; Drummond, Daryl C. Share Save Targeting EphA2 in bladder cancer using a novel antibody-directed nanotherapeuticKamoun, Walid; Swindell, Elden; Pien, Christine; Luus, Lia; Cain, Jason; Kandela, Irawati; Huang, Richard; Tipparaju, Suresh; Kirpotin, Dmitri; Bshara, Wiam; Askoxylakis, Vasileios; Morrison, Carl; Drummond, Daryl Share Save Mechanisms of synergy of carboplatin and an EphA2-targeted docetaxel antibody-directed nanotherapeuticKamoun, Walid S.; Sawyer, Andrew J.; Pien, Christine; Koshkaryev, Alexander; Luus, Lia; Merrigan, Samantha; Sun, Gang; Kozin, Sergey; Huang, Zhaohua Richard; Tipparaju, Suresh K.; Kirpotin, Dmitri B.; Xu, Hannah; Askoxylakis, Vasileios; Reynolds, Patrick C.; Drummond, Daryl C. Share Save Share Save Activity of an EphA2-targeted docetaxel nanoliposome in pancreatic patient-derived models as monotherapy and in combination with gemcitabineDrummond, Daryl C.; Straubinger, Ninfa L.; Chaudhuri, Tista Roy; Moser, Michael; Kamoun, Walid S.; Luus, Lia; Huang, Zhaohua Richard; Tipparaju, Suresh; Gillard, Bryan; Morrison, Carl; Repasky, Elizabeth; Kirpotin, Dmitri B.; Straubinger, Robert M. Share Save Nanoliposomal targeting of ephrin receptor A2 (EphA2): Preclinical in vitro and in vivo rationaleKamoun, Walid S.; Luus, Lia; Pien, Christine; Kornaga, Tad; Oyama, Shinji; Huang, Zhaohua Richard; Tipparaju, Suresh; Kirpotin, Dmitri B.; Marks, James D.; Koshkaryev, Alexander; Geddie, Melissa; Xu, Lihui; Lugovosky, Alexey; Drummond, Daryl C. Share Save 
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