Maire F. Osborn - Publications, H-index & Citations

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Maire F. Osborn

university of massachusetts system

17H-index

30Paper Count

1.4KCitation Count

Published Papers 19

Publication Date

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

NUCLEIC ACIDS RESEARCH

IF13.1

2018-12-14

137

OAAI

Biscans, Annabelle; Coles, Andrew; Haraszti, Reka; Echeverria, Dimas; Hassler, Matthew; Osborn, Maire; Khvorova, Anastasia

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

NUCLEIC ACIDS RESEARCH

IF13.1

2018-12-08

101

OAAI

Osborn, Maire F.; Coles, Andrew H.; Biscans, Annabelle; Haraszti, Reka A.; Roux, Loic; Davis, Sarah; Ly, Socheata; Echeverria, Dimas; Hassler, Matthew R.; Godinho, Bruno M. D. C.; Nikon, Mehran; Khvorova, Anastasia

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Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo

BIOCONJUGATE CHEMISTRY

IF3.9

2018-06-13

PREAI

Sharma, Vivek K.; Osborn, Maire F.; Hassler, Matthew R.; Echeverria, Dimas; Ly, Socheata; Ulashchik, Egor A.; Martynenko-Makaev, Yury, V; Shmanai, Vadim V.; Zatsepin, Timofei S.; Khvorova, Anastasia; Watts, Jonathan K.

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Improving Small Interfering RNA Delivery In Vivo Through Lipid Conjugation

NUCLEIC ACID THERAPEUTICS

IF4.7

2018-06-01

110

OAAI

Osborn, Maire F.; Khvorova, Anastasia

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Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs

MOLECULAR CANCER THERAPEUTICS

IF5.5

2018-05-31

OAAI

Osborn, Maire F.; Coles, Andrew H.; Golebiowski, Diane; Echeverria, Dimas; Moazami, Michael P.; Watts, Jonathan K.; Sena-Esteves, Miguel; Khvorova, Anastasia

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

NUCLEIC ACIDS RESEARCH

IF13.1

2018-02-08

145

OAAI

Hassler, Matthew R.; Turanov, Anton A.; Alterman, Julia F.; Haraszti, Reka A.; Coles, Andrew H.; Osborn, Maire F.; Echeverria, Dimas; Nikan, Mehran; Salomon, William E.; Roux, Loic; Godinho, Bruno M. D. C.; Davis, Sarah M.; Morrissey, David V.; Zamore, Phillip D.; Karumanchi, S. Ananth; Moore, Melissa J.; Aronin, Neil; Khvorova, Anastasia

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Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain

BIOCONJUGATE CHEMISTRY

IF3.9

2017-05-10

OAAI

Nikan, Mehran; Osborn, Maire F.; Coles, Andrew H.; Biscans, Annabelle; Godinho, Bruno M. D. C.; Haraszti, Reka A.; Sapp, Ellen; Echeverria, Dimas; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

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Robust modulation of gene expression in aggressive glioblastoma mouse models: A new approach for in vivo target validation

CANCER RESEARCH

IF16.6

2016-05-13

PREAI

Coles, Andrew H.; Osbor, Maire F.; Golebowski, Diane; Hassler, Matthew; Esteves, Miguel S.; Khvorova, Anastasia

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A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo

NUCLEIC ACID THERAPEUTICS

IF4.7

2016-04-01

OAAI

Coles, Andrew H.; Osborn, Maire F.; Alterman, Julia F.; Turanov, Anton A.; Godinho, Bruno M. D. C.; Kennington, Lori; Chase, Kathryn; Aronin, Neil; Khvorova, Anastasia

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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2016-01-01

OAAI

Nikan, Mehran; Osborn, Maire F.; Coles, Andrew H.; Godinho, Bruno M. D. C.; Hall, Lauren M.; Haraszti, Reka A.; Hassler, Matthew R.; Echeverria, Dimas; Aronin, Neil; Khvorova, Anastasia

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Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

NUCLEIC ACIDS RESEARCH

IF13.1

2015-09-22

OAAI

Osborn, Maire F.; Alterman, Julia F.; Nikan, Mehran; Cao, Hong; Didiot, Marie C.; Hassler, Matthew R.; Coles, Andrew H.; Khvorova, Anastasia

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Taking charge of siRNA delivery (vol 32, pg 1197, 2014)

NATURE BIOTECHNOLOGY

IF41.7

2015-05-12

OAAI

Khvorova, Anastasia; Osborn, Maire F.; Hassler, Matthew R.

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Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2015-01-01

123

OAAI

Alterman, Julia F.; Hall, Lauren M.; Coles, Andrew H.; Hassler, Matthew R.; Didiot, Marie-Cecile; Chase, Kathryn; Abraham, Jasmin; Sottosanti, Emily; Johnson, Emily; Sapp, Ellen; Osborn, Maire F.; Difiglia, Marian; Aronin, Neil; Khvorova, Anastasia

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Taking charge of siRNA delivery

NATURE BIOTECHNOLOGY

IF41.7

2014-12-09

PREAI

Khvorova, Anastasia; Osborn, Maire F.; Hassler, Matthew R.

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Platinum-RNA Modifications Following Drug Treatment in S. cerevisiae Identified by Click Chemistry and Enzymatic Mapping

ACS CHEMICAL BIOLOGY

IF3.8

2014-08-15