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J

Jean Sévigny

chu de québec - université laval

62H-index
357Paper Count
1.5WCitation Count
Published Papers 163
Publication Date
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Nucleotide-Derived Competitive Inhibitors of Ectonucleotidase CD39─A Promising Extracellular Target for Immunotherapy of Cancer
errJournal of Medicinal Chemistry
IF6.8
err2026-05-01
err0
errOAAI
errChunyang Bi; Florian Schwermer; Laura Schäkel; Salahuddin Mirza; Helay Baburi; Patrick Riziki; Constanze C. Schmies; Riekje Winzer; Riham Idris; Georg Rolshoven; Julia Schilling; Leon Luckenbach; Julie Pelletier; Luca Svolacchia Brusoni; Haneen Al Hroub; Ghazl Al Hamwi; Vittoria Lopez; Areso Ahmadsay; Luca Raulien; Katharina Sylvester; Jean Sévigny; Eva Tolosa; Andreas H. Guse; Christa E. Müller
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Quinoline carboxylic acid derivatives as inhibitors of NPPs: Synthesis, in silico and in vitro evaluation
errJournal of Molecular Structure
IF4.7
err2026-01-16
err0
PREAI
errNayab Syed; Aqsa Ishaq; Tajamul Hussain; Salman Alrokayan; Julie Pelletier; Jean Sévigny; Qing Huang; Jamshed Iqbal
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errSave
P2Y2 Receptor Signaling in Health and Disease
errInternational Journal of Molecular Sciences 2025, Vol. 26, Page 9815
IF0
err2025-10-09
err0
errOAAI
errFatemeh Salarpour; Jean Sévigny
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errSave
Synthesis, Biological Evaluation and Molecular Docking Studies of Novel 4-Propylsulfonylpiperazines-Based Thiosemicarbazones as Ecto-5′-Nucleotidase and NTPDase Inhibitors
errArchiv der Pharmazie
IF3.6
err2025-09-28
err0
PREAI
errHina Aftab; Shireen Mona Dutt; Suraj N. Mali; Erica Vigiani; Julie Pelletier; Jean Sévigny; Shailesh S. Gurav; Rahul D. Jawarkar; Abdulraheem SA Almalki; Muhammad Safwan Akram; Zahra Batool; Silvia Schenone; Jamshed Iqbal; Zahid Shafiq
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N-hexylsulfonyl indole based thiosemicarbazones as potent and selective ecto-5′-nucleotidase and NTPDase inhibitors
errBioorganic Chemistry
IF4.7
err2025-07-01
err0
PREAI
errZahra Batool; Shireen Mona Dutt; Mariya al-Rashida; Nicolly Espindola Gelsleichter; Julie Pelletier; Jean Sévigny; Talha Islam; Hina Aftab; Tahani Mazyad Almutairi; Furkan Çakır; Zahid Shafiq; Jamshed Iqbal
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errSave
Design, synthesis and in vitro and in silico evaluation of novel nalidixic acid derivatives as potent ectonucleotidases inhibitors
errJOURNAL OF MOLECULAR STRUCTURE
IF4.7
err2025-06-03
err0
PREAI
errAmina, Bibi; Nawaz, Ismat; Rai, Damita; Sevigny, Jean; Alrokayan, Salman; Muhammad, Muhammad; Huang, Qing
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errSave
Assessing Ecto-5'-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cells
errNEUROCHEMICAL RESEARCH
IF3.8
err2025-05-14
err0
PREAI
errManica, Fabiana M.; Campesato, Luis Felipe I.; Scholl, Juliete Nathali; Braganhol, Elizandra; Bergamin, Leticia S.; Edelweiss, Maria Isabel A.; Lenz, Guido; Sevigny, Jean; Figueiro, Fabricio; Battastini, Ana Maria O.
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Synthesis, Characterization, Interactions, and Immunomodulatory Function of Ectonucleotidase CD39/CD73 Inhibitor 8-Butylthioadenosine 5′-Monophosphate
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-04-03
err0
PREAI
errBi, CY; Mirza, S; Baburi, H; Schäkel, L; Winzer, R; Moschütz, S; Keetz, K; Lopez, V; Pelletier, J; Sévigny, J; zur Wiesch, JS; Claff, T; Tolosa, E; Namasivayam, V; Sträter, N; Müller, CE
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errSave
Ectonucleotidase inhibitors: an updated patent review (2017-2023)
errEXPERT OPINION ON THERAPEUTIC PATENTS
IF4.6
err2024-10-30
err0
PREAI
errIqbal, Jamshed; Bano, Sehrish; Khan, Imtiaz Ali; Sevigny, Jean; Huang, Qing
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errSave
CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2024-06-28
err3
errOAAI
errWu, Xiangni; Chen, Pin-, I; Whitener, Robert L.; MacDougall, Matthew S.; Coykendall, Vy M. N.; Yan, Hao; Kim, Yong Bin; Harper, William; Pathak, Shiva; Iliopoulou, Bettina P.; Hestor, Allison; Saunders, Diane C.; Spears, Erick; Sevigny, Jean; Maahs, David M.; Basina, Marina; Sharp, Seth A.; Gloyn, Anna L.; Powers, Alvin C.; Kim, Seung K.; Jensen, Kent P.; Meyer, Everett H.
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Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/ phosphodiesterase-1 and-3 inhibitors
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2024-05-01
err3
PREAI
errTasleem, Mussarat; Pelletier, Julie; Sevigny, Jean; Hussain, Zahid; Khan, Ajmal; Al-Harrasi, Ahmed; El-kott, Attalla F.; Taslimi, Parham; Negm, Sally; Shafiq, Zahid; Iqbal, Jamshed
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errSave
Extracellular nucleotides in smooth muscle contraction
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-02-01
err0
PREAI
errKammoe, Romuald Brice Babou; Sevigny, Jean
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errSave
Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme
errPURINERGIC SIGNALLING
IF2.4
err2023-10-31
err1
PREAI
errda Silva, Alisson Coldebella; Scholl, Juliete Nathali; de Fraga Dias, Amanda; Weber, Augusto Ferreira; Morrone, Fernanda Bueno; Cruz-Lopez, Olga; Conejo-Garcia, Ana; Campos, Joaquin Maria; Sevigny, Jean; Figueiro, Fabricio; Battastini, Ana Maria Oliveira
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errSave
Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2023-08-29
err3
errOAAI
errLopez, Vittoria; Schuh, H. J. Maximilian; Mirza, Salahuddin; Vaassen, Victoria J.; Schmidt, Michael S.; Sylvester, Katharina; Idris, Riham M.; Renn, Christian; Schaekel, Laura; Pelletier, Julie; Sevigny, Jean; Naggi, Annamaria; Scheffler, Bjoern; Lee, Sang-Yong; Bendas, Gerd; Mueller, Christa E.
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errSave
Resistance training reduces platelet activation in hypertensive women: the role of purinergic signaling
errJOURNAL OF HYPERTENSION
IF4.1
err2023-08-09
err0
PREAI
errCardoso, Andreia Machado; Aneli, Nyasmin Mendes; Lammers, Monica; Manica, Aline; Zanini, Daniela; Maciel, Sarah Franco Vieira de Oliveira; Sevigny, Jean; Corralo, Vanessa da Silva; De Sa, Clodoaldo Antonio
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Synthesis of Thieno[3,2-d]pyrimidine Derivatives through Sequential SNAr and Suzuki Reactions as Selective h-NTPDase Inhibitors
errCHEMMEDCHEM
IF3.4
err2023-05-31
err3
PREAI
errZaman, Gohar; Ullah, Saif; Uzair, Muhammad; Batool, Sania; Ahmad, Haseen; Ullah, Farman; Pelletier, Julia; Sevigny, Jean; Iqbal, Jamshed; Hassan, Abbas
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Tumor-neutrophil crosstalk promotes in vitro and in vivo glioblastoma progression
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2023-05-24
err11
errOAAI
errRubenich, Dominique S.; de Souza, Priscila O.; Omizzollo, Natalia; Aubin, Mariana R.; Basso, Paulo J.; Silva, Luisa M.; da Silva, Eloisa M.; Teixeira, Fernanda C.; Gentil, Gabriela F. S.; Domagalski, Jordana L.; Cunha, Maico T.; Gadelha, Kerolainy A.; Diel, Leonardo F.; Gelsleichter, Nicolly E.; Rubenich, Aline S.; Lenz, Gabriela S.; de Abreu, Aline M.; Kroeff, Giselle M.; Paz, Ana H.; Visioli, Fernanda; Lamers, Marcelo L.; Wink, Marcia R.; Worm, Paulo V.; Araujo, Anelise B.; Sevigny, Jean; Camara, Niels O. S.; Ludwig, Nils; Braganhol, Elizandra
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Stomach-derived human insulin-secreting organoids restore glucose homeostasis
errNATURE CELL BIOLOGY
IF19.1
err2023-04-27
err21
PREAI
errHuang, Xiaofeng; Gu, Wei; Zhang, Jiaoyue; Lan, Ying; Colarusso, Jonathan L.; Li, Sanlan; Pertl, Christoph; Lu, Jiaqi; Kim, Hyunkee; Zhu, Jian; Breault, David T.; Sevigny, Jean; Zhou, Qiao
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Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors
errSTEM CELL RESEARCH & THERAPY
IF7.3
err2023-04-19
err2
errOAAI
errNoronha-Matos, Jose Bernardo; Pinto-Cardoso, Rui; Bessa-Andres, Catarina; Magalhaes-Cardoso, Maria Teresa; Ferreirinha, Fatima; Costa, Maria Adelina; Marinhas, Jose; Freitas, Rolando; Lemos, Rui; Vilaca, Adelio; Oliveira, Antonio; Pelletier, Julie; Sevigny, Jean; Correia-de-Sa, Paulo
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UTP increases wound healing in the self assembled skin substitute (SASS)
errcell communication and signaling
IF3.9
err2023-02-01
err4
errOAAI
errNaasani, Liliana I. Sous; Sevigny, Jean; Moulin, Veronique J.; Wink, Marcia Rosangela
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Research Directions

No research directions
Co-authors
Cooperation Journals
A
Abdullah M. Asiri
H-index: 168 · Papers: 2.9K
C
Christian Weber
H-index: 160 · Papers: 1.8K
K
Klaus Ley
H-index: 137 · Papers: 968
V
Val C. Sheffield
H-index: 111 · Papers: 463
L
Leonard D. Shultz
H-index: 107 · Papers: 654
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