Not logged in First-in-human global study of RLY-2608, a panmutant and isoform selective PI3Ka inhibitor, as a single agent in patients with advanced solid tumors and in combination with fulvestrant in patients with advanced breast cancer Varkaris, Andreas; Jhaveri, Komal; Cabanas, Elena Garralda; Sanz, Lucia; Kim, Janice; Perez, Cesar A.; Hamilton, Erika; Spira, Alexander I.; Wisinski, Kari; Guerrero, Angel; Henry, Jason; Ahnert, Jordi Rodon; Tan, Gege; Li, Xiaoyan; Hummel, Diana; Hunter, Tamieka; Timm, Alison; Samadani, Ramin; Puente-Poushnejad, Erika; Kwak, Eunice; Mar, Brenton G.; Schram, Alison M. Share Save
A first-inhuman study of the highly selective PI3Ka inhibitor RLY-5836 in patients with advanced breast cancer and other solid tumors Varkaris, Andreas; Isakoff, Steven; Perez, Cesar A.; O'Neil, Bert; Hamilton, Erika; Conlin, Erin; Tan, Gege; Li, Xiaoyan; Timm, Alison; Samadani, Ramin; Puente-Poushnejad, Erika; Kwak, Eunice; Mar, Brenton G.; Schram, Alison M. Share Save
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia Varkaris, Andreas; Pazolli, Ermira; Gunaydin, Hakan; Wang, Qi; Pierce, Levi; Boezio, Alessandro A.; Bulku, Artemisa; Dipietro, Lucian; Fridrich, Cary; Frost, Adam; Giordanetto, Fabrizio; Hamilton, Erika P.; Harris, Katherine; Holliday, Michael; Hunter, Tamieka L.; Iskandar, Amanda; Ji, Yongli; Larivee, Alexandre; Larochelle, Jonathan R.; Lescarbeau, Andre; Llambi, Fabien; Lormil, Brenda; Mader, Mary M.; Mar, Brenton G.; Martin, Iain; Mclean, Thomas H.; Michelsen, Klaus; Pechersky, Yakov; Puente-Poushnejad, Erika; Raynor, Kevin; Rogala, Dipali; Samadani, Ramin; Schram, Alison M.; Shortsleeves, Kelley; Swaminathan, Sweta; Tajmir, Shahein; Tan, Gege; Tang, Yong; Valverde, Roberto; Wehrenberg, Bryan; Wilbur, Jeremy; Williams, Bret R.; Zeng, Hongtao; Zhang, Hanmo; Walters, W. Patrick; Wolf, Beni B.; Shaw, David E.; Bergstrom, Donald A.; Watters, James; Fraser, James S.; Fortin, Pascal D.; Kipp, D. Randal Share Save
First-in-human global multi-center study of RLY-2608, a pan mutant and isoform selective PI3Kα inhibitor, as a single agent in advanced solid tumor patients and in combination with fulvestrant in patients with advanced breast cancer Varkaris, Andreas; Hamilton, Erika; Henry, Jason; Spira, Alexander I.; Schram, Alison M.; McGuinness, Julia E.; Tan, Gege; Li, Xiaoyan; Hunter, Tamieka; Samadani, Ramin; Timm, Alison; Karanovic, Djuro; Subbiah, Vivek; Perez, Cesar A. Share Save
CD73 inhibitor oleclumab plus osimertinib for advanced EGFRm NSCLC: First report of a Phase 1b/2 study. Kim, Dong-Wan; Kim, Sang-We; Camidge, D. Ross; Rizvi, Naiyer A.; Marrone, Kristen A.; Le, Xiuning; Blakely, Collin; Park, Keunchil; Chang, Gee-Chen; Patel, Sandip Pravin; Cooper, Zachary A.; Kumar, Rakesh; Samadani, Ramin; McCombs, Rebecca; Pluta, Michael; Wu, Kevin Yufeng; Ramalingam, Suresh Share Save
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress Martinez, Ramon, III; Huang, Weiliang; Samadani, Ramin; Mackowiak, Bryan; Centola, Garrick; Chen, Lijia; Conlon, Ivie L.; Hom, Kellie; Kane, Maureen A.; Fletcher, Steven; Shapiro, Paul Share Save
Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib) Germann, Ursula A.; Furey, Brinley F.; Markland, William; Hoover, Russell R.; Aronov, Alex M.; Roix, Jeffrey J.; Hale, Michael; Boucher, Diane M.; Sorrell, David A.; Martinez-Botella, Gabriel; Fitzgibbon, Matthew; Shapiro, Paul; Wick, Michael J.; Samadani, Ramin; Meshaw, Kathryn; Groover, Anna; DeCrescenzo, Gary; Namchuk, Mark; Emery, Caroline M.; Saha, Saurabh; Welsch, Dean J. Share Save
Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity Shah, Nirav G.; Tulapurkar, Mohan E.; Ramarathnam, Aparna; Brophy, Amanda; Martinez, Ramon, III; Hom, Kellie; Hodges, Theresa; Samadani, Ramin; Singh, Ishwar S.; MacKerell, Alexander D., Jr.; Shapiro, Paul; Hasday, Jeffrey D. Share Save
Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf Samadani, Ramin; Zhang, Jun; Brophy, Amanda; Oashi, Taiji; Priyakumar, U. Deva; Raman, E. Prabhu; St John, Franz J.; Jung, Kwan-Young; Fletcher, Steven; Pozharski, Edwin; MacKerell, Alexander D., Jr.; Shapiro, Paul Share Save
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A docking domain directed inhibitor targeting ERK regulated F-site substrates Zhang, Jun; Oashi, Taiji; Semadani, Ramin; Nevels, Kerrick; Burkhard, Kimberly; Priyakumar, Deva; Raman, Prabhu; Fletcher, Steven; Pozharsky, Edvin; Shapiro, Paul; MacKerell, Alexander Share Save
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