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Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras Parry, Charles W.; Pellicano, Francesca; Schuttelkopf, Alexander W.; Beyer, Kim S.; Bower, Justin; Bryson, Amy; Cameron, Kenneth; Cerutti, Nichole M.; Clark, Jonathan P.; Davidson, Stuart C.; Davies, Keneth; Drysdale, Martin J.; Engelman, Jeffrey; Estevan-Barber, Anna; Gohlke, Andrea; Gray, Christopher H.; Guthy, Daniel A.; Hong, Min; Hopkins, Alana; Hutchinson, Luke D.; Konczal, Jennifer; Maira, Michel; McArthur, Duncan; Mezna, Mokdad; McKinnon, Heather; Nepravishta, Ridvan; Ostermann, Nils; Pasquali, Camila C.; Pollock, Katie; Pugliese, Angelo; Rooney, Nicholas; Schmiedeberg, Niko; Shaw, Paul; Velez-Vega, Camilo; West, Christopher; West, Ryan; Zecri, Frederic; Taylor, John B. Share Save
Expressed Barcoding Enables High-Resolution Tracking of the Evolution of Drug Tolerance Cotton, Jennifer L.; Diez, Javier Estrada; Sagar, Vivek; Chen, Julie; Piquet, Michelle; Alford, John; Song, Youngchul; Li, Xiaoyan; Riester, Markus; Dimare, Matthew T.; Schumacher, Katja; Boulay, Gaylor; Sprouffske, Kathleen; Fan, Lin; Burks, Tyler; Mansur, Leandra; Wagner, Joel; Bhang, Hyo-eun C.; Iartchouk, Oleg; Reece-Hoyes, John; Morris, Erick J.; Hammerman, Peter S.; Ruddy, David A.; Korn, Joshua M.; Engelman, Jeffrey A.; Niederst, Matthew J. Share Save
A landscape of response to drug combinations in non-small cell lung cancer Nair, Nishanth Ulhas; Greninger, Patricia; Zhang, Xiaohu; Friedman, Adam A.; Amzallag, Arnaud; Cortez, Eliane; Sahu, Avinash Das; Lee, Joo Sang; Dastur, Anahita; Egan, Regina K.; Murchie, Ellen; Ceribelli, Michele; Crowther, Giovanna S.; Beck, Erin; McClanaghan, Joseph; Klump-Thomas, Carleen; Boisvert, Jessica L.; Damon, Leah J.; Wilson, Kelli M.; Ho, Jeffrey; Tam, Angela; McKnight, Crystal; Michael, Sam; Itkin, Zina; Garnett, Mathew J.; Engelman, Jeffrey A.; Haber, Daniel A.; Thomas, Craig J.; Ruppin, Eytan; Benes, Cyril H. Share Save
Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors Tiedt, Ralph; King, Frederick J.; Stamm, Christelle; Niederst, Matthew J.; Delach, Scott; Zumstein-Mecker, Sabine; Meltzer, Jodi; Mulford, Iain J.; Labrot, Emma; Engstler, Barbara Schacher; Baltschukat, Sabrina; Kerr, Grainne; Golji, Javad; Wyss, Daniel; Schnell, Christian; Ainscow, Edward; Engelman, Jeffrey A.; Sellers, William R.; Barretina, Jordi; Caponigro, Giordano; Porta, Diana Graus Share Save
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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy Bonazzi, Simone; d'Hennezel, Eva; Beckwith, Rohan E. J.; Xu, Lei; Fazal, Aleem; Magracheva, Anna; Ramesh, Radha; Cernijenko, Artiom; Antonakos, Brandon; Bhang, Hyo-eun C.; Caro, Roxana Garcia; Cobb, Jennifer S.; Ornelas, Elizabeth; Ma, Xiaolei; Wartchow, Charles A.; Clifton, Matthew C.; Forseth, Ry R.; Fortnam, Bethany Hughes; Lu, Hongbo; Csibi, Alfredo; Tullai, Jennifer; Carbonneau, Seth; Thomsen, Noel M.; Larrow, Jay; Chie-Leon, Barbara; Hainzl, Dominik; Gu, Yi; Lu, Darlene; Meyer, Matthew J.; Alexander, Dylan; Kinyamu-Akunda, Jacqueline; Sabatos-Peyton, Catherine A.; Dales, Natalie A.; Zecri, Frederic J.; Jain, Rishi K.; Shulok, Janine; Wang, Y. Karen; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Engelman, Jeffrey A.; Dranoff, Glenn; Bradner, James E.; Visser, Michael; Solomon, Jonathan M. Share Save
RETRACTION: EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers (Retraction of Vol 18, Pg 74, 2011) Garofalo, Michela; Romano, Giulia; Di Leva, Gianpiero; Nuovo, Gerard; Jeon, Young-Jun; Ngankeu, Apollinaire; Sun, Jin; Lovat, Francesca; Alder, Hansjuerg; Condorelli, Gerolama; Engelman, Jeffrey A.; Ono, Mayumi; Rho, Jin Kyung; Cascione, Luciano; Volinia, Stefano; Nephew, Kenneth P.; Croce, Carlo M. Share Save
A large cellular screen charting the landscape of synergistic drug combinations in lung cancer. Nair, Nishanth Ulhas; Friedman, Adam; Greninger, Patricia; Sahu, Avinash D.; Murchie, Ellen; Crowther, Giovanna Stein; McClanaghan, Joe; Lee, Joo Sang; Haber, Daniel A.; Engelman, Jeffrey; Ruppin, Eytan; Benes, Cyril Share Save
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Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer Pereira, Bernard; Chen, Christopher T.; Goyal, Lipika; Walmsley, Charlotte; Pinto, Christopher J.; Baiev, Islam; Allen, Read; Henderson, Laura; Saha, Supriya; Reyes, Stephanie; Taylor, Martin S.; Fitzgerald, Donna M.; Broudo, Maida Williams; Sahu, Avinash; Gao, Xin; Winckler, Wendy; Brannon, A. Rose; Engelman, Jeffrey A.; Leary, Rebecca; Stone, James R.; Campbell, Catarina D.; Juric, Dejan Share Save
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms Wang, Ye; Mohseni, Morvarid; Grauel, Angelo; Diez, Javier Estrada; Guan, Wei; Liang, Simon; Choi, Jiyoung Elizabeth; Pu, Minying; Chen, Dongshu; Laszewski, Tyler; Schwartz, Stephanie; Gu, Jane; Mansur, Leandra; Burks, Tyler; Brodeur, Lauren; Velazquez, Roberto; Kovats, Steve; Pant, Bhavesh; Buruzula, Giri; Deng, Emily; Chen, Julie T.; Sari-Sarraf, Farid; Dornelas, Christina; Varadarajan, Malini; Yu, Haiyan; Liu, Chen; Lim, Joanne; Hao, Huai-Xiang; Jiang, Xiaomo; Malamas, Anthony; LaMarche, Matthew J.; Geyer, Felipe Correa; McLaughlin, Margaret; Costa, Carlotta; Wagner, Joel; Ruddy, David; Jayaraman, Pushpa; Kirkpatrick, Nathaniel D.; Zhang, Pu; Iartchouk, Oleg; Aardalen, Kimberly; Cremasco, Viviana; Dranoff, Glenn; Engelman, Jeffrey A.; Silver, Serena; Wang, Hongyun; Hastings, William D.; Goldoni, Silvia Share Save
TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts Grauel, Angelo L.; Nguyen, Beverly; Ruddy, David; Laszewski, Tyler; Schwartz, Stephanie; Chang, Jonathan; Chen, Julie; Piquet, Michelle; Pelletier, Marc; Yan, Zheng; Kirkpatrick, Nathaniel D.; Wu, Jincheng; deWeck, Antoine; Riester, Markus; Hims, Matt; Geyer, Felipe Correa; Wagner, Joel; MacIsaac, Kenzie; Deeds, James; Diwanji, Rohan; Jayaraman, Pushpa; Yu, Yenyen; Simmons, Quincey; Weng, Shaobu; Raza, Alina; Minie, Brian; Dostalek, Mirek; Chikkegowda, Pavitra; Ruda, Vera; Iartchouk, Oleg; Chen, Naiyan; Thierry, Raphael; Zhou, Joseph; Pruteanu-Malinici, Iulian; Fabre, Claire; Engelman, Jeffrey A.; Dranoff, Glenn; Cremasco, Viviana Share Save
A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts Palmer, Adam C.; Plana, Deborah; Gao, Hui; Korn, Joshua M.; Yang, Guizhi; Green, John; Zhang, Xiamei; Velazquez, Roberto; McLaughlin, Margaret E.; Ruddy, David A.; Kowal, Colleen; Muszynski, Julie; Bullock, Caroline; Rivera, Stacy; Rakiec, Daniel P.; Elliott, GiNell; Fordjour, Paul; Meyer, Ronald; Loo, Alice; Kurth, Esther; Engelman, Jeffrey A.; Bitter, Hans; Sellers, William R.; Williams, Juliet A.; Sorger, Peter K. Share Save
PTEN loss mediates clinical cross-resistance to CDK4/6 and PI3Ka inhibitors in breast cancer Costa, Carlotta; Wang, Ye; Ly, Amy; Hosono, Yasuyuki; Murchie, Ellen; Walmsley, Charlotte S.; Huynh, Tiffany; Healy, Christopher; Peterson, Rachel; Yanase, Shogo; Jakubik, Charles T.; Henderson, Laura E.; Damon, Leah J.; Timonina, Daria; Sanidas, Ioannis; Pinto, Christopher J.; Mino-Kenudson, Mari; Stone, James; Dyson, Nicholas J.; Ellisen, Leif W.; Bardia, Aditya; Ebi, Hiromichi; Benes, Cyril H.; Engelman, Jeffrey A.; Juric, Dejan Share Save
Combinations of SHP2 inhibitor to overcome RAS activation by receptor tyrosine kinases in response to ERK inhibition Hao, Huaixiang; Liu, Chen; Wang, Hongyun; Lu, Hengyu; Delach, Scott; LaMarche, Matthew; Engelman, Jeffrey; Hammerman, Peter; Caponigro, Giordano; Moody, Susan; Mohseni, Morvarid Share Save
PTEN Loss Mediates Clinical Cross-Resistance to CDK4/6 and PI3Kα Inhibitors in Breast Cancer Costa, Carlotta; Wang, Ye; Ly, Amy; Hosono, Yasuyuki; Murchie, Ellen; Walmsley, Charlotte S.; Huynh, Tiffany; Healy, Christopher; Peterson, Rachel; Yanase, Shogo; Jakubik, Charles T.; Henderson, Laura E.; Damon, Leah J.; Timonina, Daria; Sanidas, Ioannis; Pinto, Christopher J.; Mino-Kenudson, Mari; Stone, James R.; Dyson, Nicholas J.; Ellisen, Leif W.; Bardia, Aditya; Ebi, Hiromichi; Benes, Cyril H.; Engelman, Jeffrey A.; Juric, Dejan Share Save
Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers Hao, Huai-Xiang; Wang, Hongyun; Liu, Chen; Kovats, Steven; Velazquez, Roberto; Lu, Hengyu; Pant, Bhavesh; Shirley, Matthew; Meyer, Matthew J.; Pu, Minying; Lim, Joanne; Fleming, Michael; Alexander, Leigh Ann; Farsidjani, Ali; LaMarche, Matthew J.; Moody, Susan; Silver, Serena J.; Caponigro, Giordano; Stuart, Darrin D.; Abrams, Tinya J.; Hammerman, Peter S.; Williams, Juliet; Engelman, Jeffrey A.; Goldoni, Silvia; Mohseni, Morvarid Share Save
Molecular barcoding and single cell approaches to investigate drug tolerance in EGFRmut NSCLC Cotton, Jennifer L.; KrishnamurthyRadhakrishna, Viveksagar; Chen, Julie; Piquet, Michelle; Wagner, Joel; Boulay, Gaylor; Sprouffske, Kathleen; Song, Youngchul; Li, Xiaoyan; Schumacher, Katja; Thierry, Raphael; Kirkpatrick, Nathaniel D.; Ruddy, David A.; Korn, Joshua; Morris, Erick J.; Hammerman, Peter S.; Engelman, Jeffrey A.; Niederst, Matthew J. Share Save
Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer Raoof, Sana; Mulford, Iain J.; Frisco-Cabanos, Heidie; Nangia, Varuna; Timonina, Daria; Labrot, Emma; Hafeez, Nafeeza; Bilton, Samantha J.; Drier, Yotam; Ji, Fei; Greenberg, Max; Williams, August; Kattermann, Krystina; Damon, Leah; Sovath, Sosathya; Rakiec, Daniel P.; Korn, Joshua M.; Ruddy, David A.; Benes, Cyril H.; Hammerman, Peter S.; Piotrowska, Zofia; Sequist, Lecia, V; Niederst, Matthew J.; Barretina, Jordi; Engelman, Jeffrey A.; Hata, Aaron N. Share Save
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