Patrick R. Sears - Publications, H-index & Citations

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Patrick R. Sears

university of north carolina

19H-index

52Paper Count

1.3KCitation Count

Published Papers 19

Publication Date

Lipid nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models

JOURNAL OF CELL SCIENCE

IF3.6

2025-10-01

OAAI

Smith, Amanda J.; Sears, Patrick R.; Hennig, Mirko; Bhattacharjee, Rumpa B.; Yin, Weining; Golliher, Hannah; Ishimaru, Daniella; Lombana, T. Noelle; Lockhart, David J.; Wustman, Brandon A.; Ostrowski, Lawrence E.

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Cells 2025, Vol. 14, Page 1460

IF5.2

2025-09-20

OAAI

Marie-Hélène Bourassa; Guillaume Sillon; Shuizi Ding; Maurizio Chioccioli; Monkol Lek; Kaiyue Ma; Alejandro Mejia-Garcia; Simon Gravel; Donald C. Vinh; Michael R. Knowles; Margaret W. Leigh; Stephanie D. Davis; Thomas Ferkol; Kenneth N. Olivier; Elizabeth N. Schecterman; Weining Yin; Patrick R. Sears; Martina Gentzsch; Susan E. Boyles; William D. Bennett; Kirby L. Zeman; Lawrence E. Ostrowski; Maimoona A. Zariwala; Adam J. Shapiro

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Development of an inhalable contrast agent targeting the respiratory tract mucus layer for pulmonary ultrasonic imaging

SCIENTIFIC REPORTS

IF3.9

2024-12-01

OAAI

Tsuruta, James K.; Sears, Patrick R.; Rebuli, Meghan E.; Weitz, Andrew S.; Durham, Phillip G.; Clapp, Phillip W.; Hill, David B.; Ostrowski, Lawrence E.; Dayton, Paul A.; Caughey, Melissa C.

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Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IF19.4

2024-04-16

OAAI

Dougherty, Gerard W.; Ostrowski, Lawrence E.; Noethe-Menchen, Tabea; Raidt, Johanna; Schramm, Andre; Olbrich, Heike; Yin, Weining; Sears, Patrick R.; Dang, Hong; Smith, Amanda J.; Beule, Achim G.; Hjeij, Rim; Rutjes, Niels; Haarman, Eric G.; Maas, Saskia M.; Ferkol, Thomas W.; Noone, Peadar G.; Olivier, Kenneth N.; Bracht, Diana C.; Barbry, Pascal; Zaragosi, Laure-Emmanuelle; Fierville, Morgane; Kliesch, Sabine; Wohlgemuth, Kai; Koenig, Julia; George, Sebastian; Loges, Niki T.; Ceppe, Agathe; Markovetz, Matthew R.; Luo, Hong; Guo, Ting; Rizk, Hoda; Eldesoky, Tarek; Dahlke, Katrin; Boldt, Karsten; Ueffing, Marius; Hill, David B.; Pang, Yuan-Ping; Knowles, Michael R.; Zariwala, Maimoona A.; Omran, Heymut

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The role of SPAG1 in the assembly of axonemal dyneins in human airway epithelia

JOURNAL OF CELL SCIENCE

IF3.6

2022-03-31

OAAI

Smith, Amanda J.; Bustamante-Marin, Ximena M.; Yin, Weining; Sears, Patrick R.; Herring, Laura E.; Dicheva, Nedyalka N.; Lopez-Giraldez, Francesc; Mane, Shrikant; Tarran, Robert; Leigh, Margaret W.; Knowles, Michael R.; Zariwala, Maimoona A.; Ostrowski, Lawrence E.

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Structural insights into the cause of human RSPH4A primary ciliary dyskinesia

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2021-06-01

OAAI

Zhao, Yanhe; Pinskey, Justine; Lin, Jianfeng; Yin, Weining; Sears, Patrick R.; Daniels, Leigh A.; Zariwala, Maimoona A.; Knowles, Michael R.; Ostrowski, Lawrence E.; Nicastro, Daniela

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Induction of ciliary orientation by matrix patterning and characterization of mucociliary transport

BIOPHYSICAL JOURNAL

IF3.1

2021-04-01

OAAI

Sears, Patrick R.; Bustamante-Marin, Ximena M.; Gong, Henry; Markovetz, Matthew R.; Superfine, Richard; Hill, David B.; Ostrowski, Lawrence E.

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Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms inChlamydomonas, causes primary ciliary dyskinesia

PLOS GENETICS

IF3.7

2020-08-07

OAAI

Bustamante-Marin, Ximena M.; Horani, Amjad; Stoyanova, Mihaela; Charng, Wu-Lin; Bottier, Mathieu; Sears, Patrick R.; Yin, Wei-Ning; Daniels, Leigh Anne; Bowen, Hailey; Conrad, Donald F.; Knowles, Michael R.; Ostrowski, Lawrence E.; Zariwala, Maimoona A.; Dutcher, Susan K.

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A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance (vol 75, pg 878, 2020)

NATURE MEDICINE

IF50

2020-01-29

OAAI

Chivukula, Raghu R.; Montoro, Daniel T.; Leung, Hui Min; Yang, Jason; Shamseldin, Hanan E.; Taylor, Martin S.; Dougherty, Gerard W.; Zariwala, Maimoona A.; Carson, Johnny; Daniels, M. Leigh Anne; Sears, Patrick R.; Black, Katharine E.; Hariri, Lida P.; Almogarri, Ibrahim; Frenkel, Evgeni M.; Vinarsky, Vladimir; Omran, Heymut; Knowles, Michael R.; Tearney, Guillermo J.; Alkuraya, Fowzan S.; Sabatini, David M.

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A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

NATURE MEDICINE

IF50

2020-01-20

OAAI

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Mice with a Deletion of Rsph1 Exhibit a Low Level of Mucociliary Clearance and Develop a Primary Ciliary Dyskinesia Phenotype

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2019-09-01

OAAI

Yin, Weining; Livraghi-Butrico, Alessandra; Sears, Patrick R.; Rogers, Troy D.; Burns, Kimberlie A.; Grubb, Barbara R.; Ostrowski, Lawrence E.

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Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance

AMERICAN JOURNAL OF HUMAN GENETICS

IF8.1

2019-02-01

OAAI

Bustamante-Marin, Ximena M.; Yin, Wei-Ning; Sears, Patrick R.; Werner, Michael E.; Brotslaw, Eva J.; Mitchell, Brian J.; Jania, Corey M.; Zeman, Kirby L.; Rogers, Troy D.; Herring, Laura E.; Refabert, Luc; Thomas, Lucie; Amselem, Serge; Escudier, Estelle; Legendre, Marie; Grubb, Barbara R.; Knowles, Michael R.; Zariwala, Maimoona A.; Ostrowski, Lawrence E.

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Direct monitoring of pulmonary disease treatment biomarkers using plasmonic gold nanorods with diffusion-sensitive OCT

NANOSCALE

IF5.1

2017-01-01

OAAI

Blackmon, R. L.; Kreda, S. M.; Sears, P. R.; Chapman, B. S.; Hill, D. B.; Tracy, J. B.; Ostrowski, L. E.; Oldenburg, A. L.

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High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source

OPTICS LETTERS

IF3.3

2016-12-02

OAAI

Barrick, Jessica; Doblas, Ana; Gardner, Michael R.; Sears, Patrick R.; Ostrowski, Lawrence E.; Oldenburg, Amy L.

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Continuous mucociliary transport by primary human airway epithelial cells in vitro

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2015-07-15

OAAI

Sears, Patrick R.; Yin, Wei-Ning; Ostrowski, Lawrence E.

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Mutations in RSPH1 Cause Primary Ciliary Dyskinesia with a Unique Clinical and Ciliary Phenotype

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

IF19.4

2014-03-15

184

OAAI

Knowles, Michael R.; Ostrowski, Lawrence E.; Leigh, Margaret W.; Sears, Patrick R.; Davis, Stephanie D.; Wolf, Whitney E.; Hazucha, Milan J.; Carson, Johnny L.; Olivier, Kenneth N.; Sagel, Scott D.; Rosenfeld, Margaret; Ferkol, Thomas W.; Dell, Sharon D.; Milla, Carlos E.; Randell, Scott H.; Yin, Weining; Sannuti, Aruna; Metjian, Hilda M.; Noone, Peadar G.; Noone, Peter J.; Olson, Christina A.; Patrone, Michael V.; Dang, Hong; Lee, Hye-Seung; Hurd, Toby W.; Gee, Heon Yung; Otto, Edgar A.; Halbritter, Jan; Kohl, Stefan; Kircher, Martin; Krischer, Jeffrey; Bamshad, Michael J.; Nickerson, Deborah A.; Hildebrandt, Friedhelm; Shendure, Jay; Zariwala, Maimoona A.

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Human airway ciliary dynamics

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2013-02-01

OAAI

Sears, Patrick R.; Thompson, Kristin; Knowles, Michael R.; Davis, C. William

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Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IF3.5

2011-08-01